Bioorganic and Medicinal Chemistry Letters p. 1251 - 1254 (1999)
Update date:2022-08-05
Topics:
Shih, Thomas L.
Candelore, Mari R.
Cascieri, Margaret A.
Chiu, Shuet-Hing L.
Colwell Jr., Lawrence F.
Deng, Liping
Feeney, William P.
Forrest, Michael J.
Hom, Gary J.
Macintyre, D. Euan
Miller, Randall R.
Stearns, Ralph A.
Strader, Catherine D.
Tota, Laurie
Wyvratt, Matthew J.
Fisher, Michael H.
Weber, Ann E.
L-770,644 (9c) is a potent and selective agonist of the human β3 adrenergic receptor (EC50 = 13 nM). It shows good oral bioavailability in both dogs and rats (%F = 27), and is a full agonist for glycerolemia in the rhesus monkey (ED50 = 0.21 mg/kg). Based on its desirable in vitro and in vivo properties, L-770,644 was chosen for further preclinical evaluation.
View MoreArshine Pharmaceutical Co., Limited
website:http://www.cnarshine.com
Contact:0731-88503671
Address:Room 1109.Block C3, Lugu Enterprise Plaza,No.27 Wenxuan Road,Changsha National Hi-Tech Industrial Development Zone,Hunan ,P.R.China
website:http://www.simagchem.com
Contact:+86-592-2680277
Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China
Evergreen Chemical Industry Ltd.
Contact:86-553-4918210
Address:6#2-602 Wanhaobailing
website:http://www.antimex.com
Contact:0086-21-50563169
Address:Room1027,No.Jinyu Road,Pudong
Contact:+86-10-59484199
Address:No.58-A1026 Liangguan Street
Doi:10.1021/jm00327a036
(1965)Doi:10.1007/s10600-013-0455-x
(2013)Doi:10.1021/jo981693t
(1999)Doi:10.1080/10426500212274
(2002)Doi:10.1016/S0040-4020(01)82767-8
(1969)Doi:10.1021/jo00009a027
(1991)
