The assembly of β-methylene-TAD, a metabolically stable analogue of the antitumor agent TAD, by the stepwise esterification of monodeprotected methylenebis-(phosphonate) benzyl esters under Mitsunobu conditions

Article abstract of DOI:10.1016/S0960-894X(99)00544-2

Synthesis of the metabolically stable analogue of thiazole-4-carboxamide adenine dinucleotide (β-methylene-TAD) was achieved via the sequential monodeprotection of tetrabenzyl methylenebis(phosphonate) after two rounds of Mitsunobu esterifications with th