The assembly of β-methylene-TAD, a metabolically stable analogue of the antitumor agent TAD, by the stepwise esterification of monodeprotected methylenebis-(phosphonate) benzyl esters under Mitsunobu conditions

DOI: 10.1016/S0960-894X(99)00544-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3069 - 3074 (1999)

Update date:2022-08-03

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Authors:

Ikeda, Hisafumi

Abushanab, Elie

Marquez, Victor E.

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Article abstract of DOI:10.1016/S0960-894X(99)00544-2

Synthesis of the metabolically stable analogue of thiazole-4-carboxamide adenine dinucleotide (β-methylene-TAD) was achieved via the sequential monodeprotection of tetrabenzyl methylenebis(phosphonate) after two rounds of Mitsunobu esterifications with th

Full text of DOI:10.1016/S0960-894X(99)00544-2

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