Chemical and Pharmaceutical Bulletin p. 81 - 84 (2000)
Update date:2022-07-31
Topics:
Murase, Masayuki
Watanabe, Kazuhiro
Yoshida, Takuji
Tobinaga, Seisho
The nucleophilic addition reaction of N-tosyl-4-oxo-4,5,6,7- tetrahydroindole (12) with the lithium salt of 1-methoxyindole (5), followed by dehydration with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) gave the derivative of 2,4'-bi-1H-indole (9) which provides a new concise synthetic method of an indole pigment of the slime mould, arcyriacyanin A. The compound was first demonstrated here to have unique inhibitory activity to a panel of human cancer cell lines and to inhibit protein kinase C and protein tyrosine kinase.
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