Quantitative structure-activity relationship study of N-(3-oxo-3,4- dihydro-2H-benzol[1,4]thiazine-6-carbonyl)guanidines as potent na/h exchange inhibitors

DOI: 10.1248/cpb.48.843

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Chemical and Pharmaceutical Bulletin p. 843 - 849 (2000)

Update date:2022-08-05

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Authors:

Yamamoto, Takeshi

Hori, Manabu

Watanabe, Ikuo

Harada, Kengo

Ikeda, Shoji

Ohtaka, Hiroshi

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Article abstract of DOI:10.1248/cpb.48.843

We have previously reported that N-(4-isopropyl-2,2-dimethyl-3-oxo-3,4- dihydro-2H-benzo[1,4]oxazine-6carbonyl)guanidine (4b) methanesulfonate salt (KB-R9032) is a potent and highly water-soluble Na/H exchange inhibitor. In a series of studies on Na/H exc

Full text of DOI:10.1248/cpb.48.843

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