Bioorganic and Medicinal Chemistry Letters p. 2129 - 2134 (2005)
Update date:2022-08-03
Topics:
Kim, Dooseop
Wang, Liping
Hale, Jeffrey J.
Lynch, Christopher L.
Budhu, Richard J.
MacCoss, Malcolm
Mills, Sander G.
Malkowitz, Lorraine
Gould, Sandra L.
Demartino, Julie A.
Springer, Martin S.
Hazuda, Daria
Miller, Michael
Kessler, Joseph
Hrin, Renee C.
Carver, Gwen
Carella, Anthony
Henry, Karen
Lineberger, Janet
Schleif, William A.
Emini, Emilio A.
A series of 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists containing a variety of fused heterocycles at the 4-position of the piperidine side chain has been discovered, which are orally bioavailable with potent anti-HIV activity.
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