Rapid entry into the cryptophycin core via an acyl-beta-lactam macrolactonization: total synthesis of cryptophycin-24.

DOI: 10.1021/ol010044s

Source and publish data:

Organic letters p. 1813 - 1815 (2001)

Update date:2022-08-02

Topics:

Authors:

Eggen Eggen

Nair Nair

Georg Georg

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Article abstract of DOI:10.1021/ol010044s

[see structure]. An efficient, concise approach to the macrolide core of the cryptophycins, potent antimitotic agents, has been achieved. The reaction sequence features a novel macrolactonization utilizing a reactive acyl-beta-lactam intermediate that inc

Full text of DOI:10.1021/ol010044s

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