A straightforward synthesis of protected isostatine from achiral precursors using the asymmetric chelate claisen rearrangement

Article abstract of DOI:10.1016/S0040-4039(98)02486-1

Starting from achiral TFA-protected glycine crotyl ester (3) the interesting, suitable protected, enantiomerically pure β-hydroxy-γ-amino isostatine (7) was synthesized in only four steps. The amino acid obtained can directly be introduced into peptides.