Preparation and pharmacological evaluation of 1-(1,4-benzoquinon-2-yl)- 1,2,3,4-tetrahydronaphthalenes as potent cerebral protective agents

DOI: 10.1248/cpb.44.132

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 132 - 138 (1996)

Update date:2022-07-30

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Authors:

Suzuki Suzuki

Tatsuoka

Ishihara

Ohno Ohno

Aisaka Aisaka

Ogino Ogino

Kuroki Kuroki

Satoh Satoh

Miyano Miyano

Sumoto Sumoto

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Article abstract of DOI:10.1248/cpb.44.132

Two new series of 1-(1,4-benzoquinon-2-yl)-1,2,3,4-tetrahydronaphthalenes (3, 4) were synthesized for evaluation of their pharmacological activities. These compounds showed significant anti-lipid peroxidation (ALP) activities with rat brain homogenate and some of them possessed a protective effect against hypobaric hypoxia in mice.

Full text of DOI:10.1248/cpb.44.132

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