STUDY ON THE BIOSYNTHESIS OF ECDYSONE PART IV: Synthesis of high specific activity -2,22-dideoxyecdysone Tissue distribution of the C-22 hydroxylase in Locusta migratoria

DOI: 10.1016/S0040-4020(01)85918-4

Source and publish data:

Tetrahedron p. 1397 - 1408 (1988)

Update date:2022-09-26

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Authors:

Haag, Thierry

Hetru, Charles

Kappler, Christine

Moustier, Anne Marie

Hoffmann, Jules A.

Luu, Bang

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Article abstract of DOI:10.1016/S0040-4020(01)85918-4

We have synthesized a tritiated form of 2,22-dideoxyecdysone <<(3)H2-22,23>-3β,14α,25-trihydroxy-5β-cholest-7-en-6-one> of high specific activity (2.2 TBq/mmol).We have examined the capacity of various endocrine (prothoracic glands, follicle cells) and peripheral (fat body, Malpighian tubules) tissues of Locusta migratoria to use this molecule as a precursor of ecdysone biosynthesis.Efficient conversion of 2,22-dideoxyecdysone to 2-deoxyecdysone and to ecdysone could principally be monitored in the prothoracic glands and follicle cells.

Full text of DOI:10.1016/S0040-4020(01)85918-4

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