Unusual reactions of secondary amino acids with trifluoroacetic anhydride: A novel access to α-trifluoromethylated acyloins

Article abstract of DOI:10.1016/0040-4039(94)88187-1

A new fragmentation reaction of secondary α-amino acids with trifluoroacetic anhydride under Dakin-West reaction conditions proceeds through oxazolium salt intermediates followed by ring cleavage to form α- trifluoromethylated acyloins in good yields.