Total synthesis of matlystatin A

DOI: 10.1016/S0040-4039(00)61363-1

Source and publish data:

Tetrahedron Letters p. 8477 - 8480 (1993)

Update date:2022-09-26

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Authors:

Tamaki, Kazuhiko

Kurihara, Shinwa

Sugimura, Yukio

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Article abstract of DOI:10.1016/S0040-4039(00)61363-1

Of the five congeners in the matlystatin series, matlystatin A (1) is the most potent inhibitor of type IV collagenase. The total synthesis of 1 was accomplished, and the absolute configuration was unambiguously determined as shown in figure I.

Full text of DOI:10.1016/S0040-4039(00)61363-1

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