Journal of Medicinal Chemistry p. 8141 - 8153 (2015)
Update date:2022-08-03
Topics:
Zachariassen, Zack G.
Karlsh?j, Stefanie
Haug, Bengt Erik
Rosenkilde, Mette M.
V?ben?, Jon
We here report an experimentally verified binding mode for the known tripeptidomimetic CXCR4 antagonist KRH-1636 (1). A limited SAR study based on the three functionalities of 1 was first conducted, followed by site-directed mutagenesis studies. The recep
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Doi:10.1055/s-0029-1219364
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