Organic & Biomolecular Chemistry
Paper
General procedure for synthesis of 1a–p
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To a mixture of o-aminoacetophenones (1.25 mmol) and
methanamines (0.5 mmol) was added Sc(OTf)3 (5 mol%). After
stirring at 90 °C under an air atmosphere for 12 h, the mixture
was extracted with CH2Cl2 and H2O. The organic layer was
dried with Na2SO4, and then concentrated in vacuo. The pro-
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gel with 5–10% ethyl acetate in petroleum ether as the eluent.
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Acknowledgements
This research was financially supported by the National Nature
Science Foundation of China (21272069, 20672035) and the
Fundamental Research Funds for the Central Universities and
Key Laboratory of Organofluorine Chemistry, Shanghai Insti-
tute of Organic Chemistry, Chinese Academy of Sciences.
Notes and references
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and products could be detected by atmospheric solids
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