Peptide coupling in the presence of highly hindered tertiary amines

DOI: 10.1021/jo950912x

Source and publish data:

Journal of Organic Chemistry p. 2460 - 2465 (1996)

Update date:2022-08-05

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Authors:

Carpino, Louis A.

Ionescu, Dumitru

El-Faham, Ayman

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Article abstract of DOI:10.1021/jo950912x

Previously, 2,4,6-trimethylpyridine (collidine), due to steric shielding around the N-atom, was found to be an efficient base for effecting peptide segment coupling via azabenzotriazole-based onium-style coupling reagents. A number of even more highly hin

Full text of DOI:10.1021/jo950912x

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