REGIOSPECIFIC SYNTHESIS OF N-ALKYL-4- AND 5-SUBSTITUTED IMIDAZOLES

Article abstract of DOI:10.3987/COM-94-6926

A facile regiospecific synthesis of 4- and 5-substituted N-alkyl imidazoles has been developed from N-trimethylsilyloxyethylimidazole(s).The method combines directed metallation with alkyl triflate mediated imidazole quaternization and SEM group cleavage.