New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6′R)-6′-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor

DOI: 10.1021/jm010374i

Source and publish data:

Journal of Medicinal Chemistry p. 748 - 751 (2002)

Update date:2022-08-05

Topics:

Authors:

Shuto, Satoshi

Minakawa, Noriaki

Niizuma, Satoshi

Kim, Hye-Sook

Wataya, Yusuke

Matsuda, Akira

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Article abstract of DOI:10.1021/jm010374i

An improved method for the synthesis of (6′R)-6′-C-methylneplanocin A (RMNPA, 2), a potent S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitor, was developed via a chelation-controlled stereoselective addition of MeTiCl₃ to the neplanocin A

Full text of DOI:10.1021/jm010374i

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Product name:(6'R)-2',3'-di-O-(tert-butyldimethylsilyl)-6'-methylnaplanocin A

Cas No:400611-68-9

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