A highly diastereoselective vinylogous Mannich condensation and 1,4-conjugate addition of (Z)-propenyl cuprate in the synthesis of an influenza neuraminidase inhibitor

DOI: 10.1016/S0957-4166(03)00597-4

Source and publish data:

Tetrahedron Asymmetry p. 3541 - 3551 (2003)

Update date:2022-08-04

Topics:

Authors:

Barnes, David M.

Bhagavatula, Lakshmi

DeMattei, John

Gupta, Ashok

Hill, David R.

Manna, Sukumar

McLaughlin, Maureen A.

Nichols, Paul

Premchandran, Ramiya

Rasmussen, Michael W.

Tian, Zhenping

Wittenberger, Steven J.

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Article abstract of DOI:10.1016/S0957-4166(03)00597-4

A practical synthesis of neuraminidase influenza inhibitor, A-322278, has been developed. Asymmetry is introduced into the synthesis by an enzyme mediated ester hydrolysis. A highly diastereoselective vinylogous Mannich condensation reaction of N-Boc-2-te

Full text of DOI:10.1016/S0957-4166(03)00597-4

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