
Chemistry Letters p. 1013 - 1014 (1999)
Update date:2022-07-30
Topics:
Miyazawa, Toshifumi
Ensatsu, Eiichi
Tanaka, Kayoko
Yanagihara, Ryoji
Yamada, Takashi
The superiority of the carbamoylmethyl ester as an acyl donor for the α-chymotrypsin-catalyzed kinetically controlled peptide synthesis was demonstrated in several segment condensations carried out in organic media with low water content. Then this approach was successfully applied to the construction of the Leuenkephalin sequence via the 4 + 1 segment condensation.
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