Glycoconj J
15. Campo, V.L., Marchiori, M.F., Rodrigues, L.C., Dias-Baruffi, M.:
Synthetic glycoconjugates inhibitors of tumor-related galectin-3: an
16. Laaf, D., Bojarova, P., Elling, L., Kren, V.: Galectin-Carbohydrate
interactions in biomedicine and biotechnology. Trends Biotechnol.
References
1. Ju, T., Otto, V.I., Cummings, R.D.: The Tn Antigen—structural
simplicity and biological complexity. Angew. Chem. Int. Ed.
2. Yu, L.G.: The oncofetal Thomsen-Friedenreich carbohydrate anti-
gen in cancer progression. Glycoconjugate J. 24(8), 411–420
17. Bumba, L., Laaf, D., Spiwok, V., Elling, L., Křen, V., Bojarová, P.:
Poly-N-Acetyllactosamine neo-glycoproteins as nanomolar ligands
of human galectin-3: Binding kinetics and modeling. Int. J. Mol.
18. Laaf, D., Bojarová, P., Pelantová, H., Křen, V., Elling, L.: Tailored
multivalent neo-glycoproteins: synthesis, evaluation, and applica-
tion of a library of galectin-3-binding glycan ligands. Bioconj.
19. Zhang, H., Laaf, D., Elling, L., Pieters, R.J.: Thiodigalactoside-
bovine serum albumin conjugates as high-potency inhibitors of
galectin-3: an outstanding example of multivalent presentation of
small molecule inhibitors. Bioconj. Chem. 29(4), 1266–1275
20. Rodriguez, M.C., Yegorova, S., Pitteloud, J.-P., Chavaroche, A.E.,
André, S., Ardá, A., Minond, D., Jiménez-Barbero, J., Gabius, H.-
J., Cudic, M.: Thermodynamic switch in binding of adhesion/
growth regulatory human galectin-3 to tumor-associated TF
Antigen (CD176) and MUC1 glycopeptides. Biochemistry.
21. Santarsia, S., Grosso, A.S., Trovão, F., Jiménez-Barbero, J.,
Carvalho, A.L., Nativi, C., Marcelo, F.: Molecular recognition of
a Thomsen–Friedenreich antigen mimetic targeting human
galectin-3. Chem Med Chem. 13(19), 2030–2036 (s). https://doi.
22. Guha, P., Kaptan, E., Bandyopadhyaya, G., Kaczanowska, S.,
Davila, E., Thompson, K., Martin, S.S., Kalvakolanu, D.V., Vasta,
G.R., Ahmed, H.: Cod glycopeptide with picomolar affinity to
galectin-3 suppresses T-cell apoptosis and prostate cancer metasta-
sis. Proc. Natl. Acad. Sci. U. S. A. 110(13), 5052–5057 (2013).
3. Almogren, A., Abdullah, J., Ghapure, K., Ferguson, K., Glinsky,
V.V., Rittenhouse-Olson, K.: Anti-Thomsen-Friedenreich-Ag (anti-
TF-Ag) potential for cancer therapy. Front. Biosci., Scholar Ed. 4,
4. Byrd, J.C., Bresalier, R.S.: Mucins and mucin binding proteins in
colorectal cancer. Cancer Metastasis Rev. 23(1/2), 77–99 (2004).
5. Jeschke, U., Karsten, U., Wiest, I., Schulze, S., Kuhn, C., Friese, K.,
Walzel, H.: Binding of galectin-1 (gal-1) to the Thomsen-
Friedenreich (TF) antigen on trophoblast cells and inhibition of
proliferation of trophoblast tumor cells in vitro by gal-1 or an
anti-TF antibody. Histochem. Cell Biol. 126(4), 437–444 (2006).
6. Glinsky, V.V., Glinsky, G.V., Rittenhouse-Olson, K., Huflejt, M.E.,
Glinskii, O.V., Deutscher, S.L., Quinn, T.P.: The role of Thomsen-
Friedenreich antigen in adhesion of human breast and prostate can-
cer cells to the endothelium. Cancer Res. 61(12), 4851–4857 (2001)
7. Glinsky, V.V., Huflejt, M.E., Glinsky, G.V., Deutscher, S.L., Quinn,
T.P.: Effects of Thomsen-Friedenreich antigen-specific peptide P-
30 on beta-galactoside-mediated homotypic aggregation and adhe-
sion to the endothelium of MDA-MB-435 human breast carcinoma
cells. Cancer Res. 60(10), 2584–2588 (2000)
8. Bian, C.-F., Zhang, Y., Sun, H., Li, D.-F., Wang, D.-C.: Structural
basis for distinct binding properties of the human galectins to
Thomsen-Friedenreich antigen. PLoS One 6(9), e25007 (2011).
doi: 10.1371/journal.pone.0025007
9. Khaldoyanidi, S.K., Glinsky, V.V., Sikora, L., Glinskii, A.B.,
Mossine, V.V., Quinn, T.P., Glinsky, G.V., Sriramarao, P.: MDA-
MB-435 human breast carcinoma cell homo- and heterotypic adhe-
sion under flow conditions is mediated in part by Thomsen-
Friedenreich antigen-galectin-3 interactions. J. Biol. Chem.
278(6), 4127–4134 (2003). doi: 10.1074/jbc.M209590200
10. Zhao, Q.C., Guo, X.L., Nash, G.B., Stone, P.C., Hilkens, J.,
Rhodes, J.M., Yu, L.G.: Circulating galectin-3 promotes metastasis
by modifying MUC1 localization on cancer cell surface. Cancer
23. Henze, M., Schmidtke, S., Hoffmann, N., Steffens, H., Pietruszka,
J., Elling, L.: Combination of glycosyltransferases and a
glycosynthase in sequential and one-pot reactions for the synthesis
of type 1 and type 2 N-acetyllactosamine oligomers. Chem Cat
11. Zhao, Q.C., Barclay, M., Hilkens, J., Guo, X.L., Barrow, H.,
Rhodes, J.M., Yu, L.G.: Interaction between circulating galectin-3
and cancer-associated MUC1 enhances tumour cell homotypic ag-
gregation and prevents anoikis. Mol Cancer. 9(1), 154 (2010).
12. Oberg, C.T., Leffler, H., Nilsson, U.J.: Inhibition of galectins with
small molecules. Chimia 65(1–2), 18–23 (2011). doi: https://doi.
13. Delaine, T., Collins, P., MacKinnon, A., Sharma, G., Stegmayr, J.,
Rajput, V.K., Mandal, S., Cumpstey, I., Larumbe, A., Salameh,
B.A., Kahl-Knutsson, B., van Hattum, H., van Scherpenzeel, M.,
Pieters, R.J., Sethi, T., Schambye, H., Oredsson, S., Leffler, H.,
Blanchard, H., Nilsson, U.J.: Galectin-3-binding glycomimetics
that strongly reduce bleomycin-induced lung fibrosis and modulate
intracellular glycan recognition. ChemBioChem. 17(18), 1759–
24. Henze, M., You, D.-J., Kamerke, C., Hoffmann, N., Angkawidjaja,
C., Ernst, S., Pietruszka, J., Kanaya, S., Elling, L.: Rational design
of a glycosynthase by the crystal structure of β-galactosidase from
Bacillus circulans (BgaC) and its use for the synthesis of N-
acetyllactosamine type 1 glycan structures. J. Biotechnol. 191(0),
25. Kamerke, C., Pattky, M., Huhn, C., Elling, L.: Synthesis of
nucleotide-activated disaccharides with recombinant β3-
galactosidase C from Bacillus circulans. J. Mol. Catal. B: Enzym.
26. Steinmann, A., Thimm, J., Matwiejuk, M., Thiem, J.: Formation of
homooligosaccharides using base-promoted glycosylation of un-
protected glycosyl fluorides. Macromolecules. 43(8), 3606–3612
27. Chen, R.F.: Removal of fatty acids from serum albumin by charcoal
treatment. J. Biol. Chem. 242(2), 173–181 (1967)
14. Cecioni, S., Imberty, A., Vidal, S.: Glycomimetics versus multiva-
lent glycoconjugates for the design of high affinity lectin ligands.
28. Böcker, S., Laaf, D., Elling, L.: Galectin binding to neo-glycopro-
teins: LacDiNAc conjugated BSA as ligand for human galectin-3.