Bioorganic and Medicinal Chemistry Letters p. 2679 - 2684 (2005)
Update date:2022-08-03
Topics:
Leonard, Kristi
Pan, Wenxi
Anaclerio, Beth
Gushue, Joan M.
Guo, Zihong
DesJarlais, Renee L.
Chaikin, Marge A.
Lattanze, Jennifer
Crysler, Carl
Manthey, Carl L.
Tomczuk, Bruce E.
Marugan, Juan Jose
We describe the synthesis and structure/activity relationship of RGD mimetics that are potent inhibitors of the integrin αvβ 3. Indol-1-yl propionic acids containing a variety of basic moieties at the 5-position, as well as substitutions alpha and beta to the carboxy terminus were synthesized and evaluated. Novel compounds with improved potency have been identified.
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