Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir)

DOI: 10.1016/S0960-894X(02)00134-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1185 - 1187 (2002)

Update date:2022-08-04

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Authors:

Sham, Hing L.

Betebenner, David A.

Chen, Xiaoqi

Saldivar, Ayda

Vasavanonda, Sudthida

Kempf, Dale J.

Plattner, Jacob J.

Norbeck, Daniel W.

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Article abstract of DOI:10.1016/S0960-894X(02)00134-8

The HIV protease inhibitor ABT-378 (Lopinavir) has a 2,6-dimethylphenoxyacetyl group in the P-2′ position. Analogues in which this group is replaced with various substituted phenyl or heteroaryl groups were synthesized and the structure-activity relationships explored.

Full text of DOI:10.1016/S0960-894X(02)00134-8

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Product name:(2,6-dimethyl-phenylsulfanyl)-acetic acid ethyl ester

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