Tetrahedron Letters p. 6915 - 6918 (2001)
Update date:2022-08-04
Topics:
Sasaki, Shigeki
Yamauchi, Hiroyuki
Nagatsugi, Fumi
Takahashi, Ryo
Taniguchi, Yosuke
Maeda, Minoru
Novel nucleoside analogs have been designed for selective formation of anti-parallel triplexes including a TA or a CG interrupting site. The new compounds are constructed of a W-shape bicyclic nucleic acid (WNA) bearing an aromatic ring as a stacking motif and a guanine for the formation of Hoogesteen hydrogen bonds, and are expected to effect triplex stabilization by both stacking and complementary hydrogen bonds. Purine-rich triplex-forming oligodeoxynucleotide (TFO) incorporating the new analog, WNA-7βG, formed a stable triplex with high selectivity to the TA site.
View MoreContact:86-311-67265101
Address:203 Lianmeng Road, Qiaoxi District
Shanghai Yongyi Biotechnology Co., Ltd
Contact:+86-0512-69561955
Address:Suite 3005, City Gateway, No.398 North CaoXi Road, XuHui District, Shanghai 200030, China.
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd
Contact:028-85317716
Address:Tianfu Life Science Park, No. 88 South Keyuan Road, Gaoxin District, Chengdu City, Sichuan Province, PRC.
zhuzhou zhongle chemical co. ltd.
Contact:+86-0731 28228409
Address:Zhuzhou, Hunan, China
Shanghai Yuking Water Soluble Material Tech Co., Ltd
Contact:86-21-68286299
Address:4F, 13B, No. 600, South Xinyuan Road 201306, Shanghai, China
Doi:10.1021/ic020522a
(2003)Doi:10.1016/S0031-9422(00)84394-0
(1976)Doi:10.1021/ja00173a040
(1990)Doi:10.1016/S0008-6215(00)83856-2
(1976)Doi:10.1016/j.chemphys.2005.01.024
(2005)Doi:10.1021/acschembio.5b01016
(2016)