Antiparasitic 5 nitrothiazoles and 5 nitro 4 thiazolines. 4

Article abstract of DOI:10.1021/jm00248a014

The synthesis and biological properties of some 2 heteroylimino 5 nitro 4 thiazoline 3 acetamides and some 1 (carbamoylmethyl) 1 (5 nitro 2 thiazolyl)ureas together with the corresponding ring N substituted [3 (carbamoylmethyl) 5 nitro 4 thiazolin 2 ylidene]ureas (I, R is NHR₁) are described. The compounds were prepared by treatment of a DMF solution of the Na salt of the appropriate amide or urea with halo acetamides. Some of them have significant antischistosome properties.