Journal of Medicinal Chemistry p. 207 - 209 (1974)
Update date:2022-08-03
Topics:
Islip
Closier
Neville
The synthesis and biological properties of some 2 heteroylimino 5 nitro 4 thiazoline 3 acetamides and some 1 (carbamoylmethyl) 1 (5 nitro 2 thiazolyl)ureas together with the corresponding ring N substituted [3 (carbamoylmethyl) 5 nitro 4 thiazolin 2 ylidene]ureas (I, R is NHR1) are described. The compounds were prepared by treatment of a DMF solution of the Na salt of the appropriate amide or urea with halo acetamides. Some of them have significant antischistosome properties.
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