Bioorganic and Medicinal Chemistry Letters p. 813 - 815 (2003)
Update date:2022-08-04
Topics:
Fukunaga, Kyoko
Yoshida, Masahiro
Nakajima, Fumio
Uematsu, Rie
Hara, Mariko
Inoue, Shintaro
Kondo, Hirosato
Nishimura, Shin-Ichiro
We have established an efficient synthesis of mimics of β-galactosylceramide (β-GalCer) increasing a β-glucocerebrosidase (β-GlcCer'ase) activity that associates with the skin barrier function. Among the synthetic β-GalCer analogues (6a-6e) described herein, compound 6e exhibited a potent effect on the activation of β-GlcCer'ase function in vitro and reduced the transepidermal water loss (TEWL) level in a UVB-induced barrier disrupted mice model. These findings indicated that compound 6e could be useful for cosmetics and medicines to improve skin barrier function.
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