Journal of Organic Chemistry p. 378 - 387 (1991)
Update date:2022-08-05
Topics:
Vaillancourt, Valerie
Agharahimi, Mohamad R.
Sundram, Uma N.
Richou, Olivier
Faulkner, D. John
Albizati, Kim F.
The syntheses of (-)-furodysin ((-2)-2a) and (-)-furodysinin ((-)-3a) in four steps starting from (+)-9-bromocamphor (18) has been accomplished, thus establishing the absolute configuration of these and related metabolites.This was made possible by the unexpected exo selectivity in the aldol condensation of camphor-like enolates with aldehydes.This has been found to be a general phenomenon in the camphor system.Further, anionic fragmentation of the C1-C7 bond of camphor derivatives has allowed access to synthetic intermediates containing functionalized six-memberedrings, thus opening up avenues from camphor to a new class of chiral pool elements not currently available from chiral pool substances.
View MoreShanghai Hanshare Industry Co.,Ltd.
Contact:86 21 20960688
Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
Hangzhou Ledun Technology Co.,Ltd.
Contact:86-571-18767088918
Address:No.6 street,XiaSha,Hangzhou,China.
Nanyang Tianhua pharmaceutical Co.,Ltd.
Contact:+8618639816203
Address:Longsheng Industrial Park
website:http://www.josunpharma.com
Contact:+86-311-80715268 80766839
Address:No.39, Zhaiying Street, Shijaizhuang,Hebei,China
Chengdu Pukang Biotechnology Co., Ltd
website:http://www.pu-kang.com
Contact:86-028-63976226
Address:No. 868 Xiwang Road,Xinjin county,Chengdu city, China
Doi:10.1021/jo025701o
(2002)Doi:10.1002/ardp.19943271005
(1994)Doi:10.1016/S0040-4039(03)01416-3
(2003)Doi:10.1046/j.1365-2044.2002.288515.x
(1891)Doi:10.1021/np030097d
(2003)Doi:10.1016/j.tetasy.2010.05.024
(2010)