Reaction of 2-thiohydantoins with some diazoalkanes and some amines

Article abstract of DOI:10.1080/10426500008043673

Reaction of 2-thiohydantoin derivatives with diazoalkanes as diazomethane, diphenyldiazomethane and/or 9-diazofluorene was investigated. Several 2-thio- and 2-methylthiohydantoins (IIa,b), (IIIa,b) (XI) and (XII) were prepared via the reaction of 2-thiohydantoins (Ia,b) and (X) with diazomethane. 2-Morpholino- and/or 2-piperidino- glycocyamidines (VIIa,b) and (XVa,b) were prepared by reacting 2-alkylthiohydantoins (IIIa) and (XII), respectively, with morpholine and/or piperidine. Moreover, treating of two equivalents of XIVa-d with one equivalent of piperazine afforded 1,4[di-(5-phenylmethylene-hydantoinyl)]-piperazines (XVIa,b). The hehaviour of 2-alkylthiohydantoins towards alanine and arthranilic acid was also investigated. The structure of the products was established by correct analytical and spectral data as well as by chemical evidencies.

Full text of DOI:10.1080/10426500008043673

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Phosphorus, Sulfur, and Silicon
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REACTION OF 2-
THIOHYDANTOINS WITH SOME
DIAZOALKANES AND SOME
AMINES
Ahmed A. El-barbary a , Youssef L. Aly b , Abdel-
Fatah M. Hashem a & Ashraf A. El-shehawy b
a Chemistry Department Faculty of Science, Tanta
University Tanta, Egypt
b Chemistry Department, Faculty of Education, Kafr
El-Sheikh, Tanta University, Egypt
Version of record first published: 04 Oct 2006.
To cite this article: Ahmed A. El-barbary, Youssef L. Aly, Abdel-Fatah M. Hashem
& Ashraf A. El-shehawy (2000): REACTION OF 2-THIOHYDANTOINS WITH SOME
DIAZOALKANES AND SOME AMINES, Phosphorus, Sulfur, and Silicon and the Related
Elements, 160:1, 77-91
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