P. Jhansi Lakshmi et al. / Bioorg. Med. Chem. 17 (2009) 6040–6047
6047
based models virtual screening was performed against Maybridge
database to find the novel non-peptide inhibitors. From this study,
we identified compound (AW1208) as a non-peptide inhibitor
against Caspase-3.
Supplementary data
Supplementary data associated with this article can be found, in
References and notes
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Figure 9. Apoptosis inhibition by AW01208.
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increase in concentrations of the lead compound AW01208. It is
evident from the graph in Figure 9 that the decrease in fluores-
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The above data obtained shows that the compound AW1208
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We have generated ligand based pharmacophore model using
25 diversed compounds. The model consisted of one H-bond
acceptor (HBA), one H-bond donor (HBD), and two hydrophobic
(HY) features. Further docking studies were performed on the
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