STEREOSELECTIVE TOTAL SYNTHESIS OF RACEMIC GRANDISOL via 3-OXIMINO-1,4,4-TRIMETHYLBICYCLOHEPTANE. AN IMPROVED PRACTICAL PROCEDURE.

Article abstract of DOI:10.1016/S0040-4020(01)96088-0

(+/-)Grandisol was stereoselectively obtained via 1,4,4-trimethylbicyclo<3.2.0>heptane-3-one and its oxime by an improved procedure. 2,5,5-trimethylhept-1,6-dien-4-ol, the open chain molecule, was synthesized by two routes.Its conversion into (+/-)grandisol was performed emploing the photobicyclization as key step.