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366789-02-8

Basic Information
CAS No.: 366789-02-8
Name: Rivaroxaban
Article Data: 105
Molecular Structure:
Molecular Structure of 366789-02-8 (Rivaroxaban)
Formula: C19H18ClN3O5S
Molecular Weight: 435.888
Synonyms: 5-Chloro-N-[[(S)-3-(4-(3-oxomorpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]-thiophene-2-carboxamide;BAY 59-7939;Xarelto;
EINECS: 685-132-2
Density: 1.46 g/cm3
Melting Point: 228-229°C
Boiling Point: 732.609 °C at 760 mmHg
Flash Point: 396.868 °C
PSA: 116.42000
LogP: 3.04080
Synthetic route
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

42518-98-9

5-chlorothiophene-2-carbonyl chloride

366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 3h; Product distribution / selectivity;100%
With triethylamine In tetrahydrofuran at 20℃; for 3h; Reagent/catalyst; Solvent; Time; Concentration; Temperature;100%
With sodium carbonate In water; acetone; toluene at 8 - 53℃; for 0.5h;98.7%
42518-98-9

5-chlorothiophene-2-carbonyl chloride

4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one diphosphate

366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With sodium carbonate In water; acetone at 10 - 50℃; for 0.5h;97.5%

(S)-N-/3-{N-[4-(3-oxomorpholine-4-yl)phenyl]-N-(ethoxycarbonyl)amino}-2-hydroxyprop-1-yl/-5-chlorothiophene-2-carboxamide

366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With potassium carbonate In methanol at 20℃; for 2h;97%

C10H11Cl2NO4S

438056-69-0

4-(4-aminophenyl)morpholin-3-one

366789-02-8

Rivaroxaban

Conditions
ConditionsYield
In ethanol at 36℃; for 7h; Solvent;96.4%
24065-33-6

5-Chlorothiophene-2-carboxylic acid

898543-06-1

4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride

366789-02-8

Rivaroxaban

Conditions
ConditionsYield
Stage #1: 5-Chlorothiophene-2-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 25℃; for 0.5h;
Stage #2: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride In N,N-dimethyl-formamide at 34℃; for 4h;
96.3%
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 2.83333h; Reagent/catalyst; Cooling with ice;95.2%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 24h; pH=8 - 9; Large scale;94.7%
42518-98-9

5-chlorothiophene-2-carbonyl chloride

1251952-62-1

4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one methanesulfonic acid salt

366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With potassium hydrogencarbonate In ethanol; water; butanone at 20 - 35℃; for 0.75h; Large scale;96%
With triethylamine In 1-methyl-pyrrolidin-2-one; toluene at 50 - 60℃; for 0.25h;81%
42518-98-9

5-chlorothiophene-2-carbonyl chloride

4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride

366789-02-8

Rivaroxaban

Conditions
ConditionsYield
Stage #1: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride With sodium carbonate In water; acetone at 8 - 12℃;
Stage #2: 5-chlorothiophene-2-carbonyl chloride In water; acetone at 50 - 53℃; for 0.5h; Temperature;
95.6%
With triethylamine In N,N-dimethyl-formamide at 30 - 40℃; for 5h;150.1 g
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

24065-33-6

5-Chlorothiophene-2-carboxylic acid

366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With 4-methyl-morpholine; hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 2.83333h;95.2%
With ortho-iodophenylboronic acid In dichloromethane at 30℃; for 48h; Reagent/catalyst; Time; Concentration; Temperature; Solvent; Dean-Stark;85%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h;68.9%
721401-53-2

5-chloro-N-{(R)‐2‐hydroxy‐3‐[4‐(3-oxo-4-morpholinyl)phenylamino]-propyl}thiophene-2-carboxamide

530-62-1

1,1'-carbonyldiimidazole

366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With dmap In acetone at 100℃; for 6h;95.1%
In 1-methyl-pyrrolidin-2-one; toluene at 20 - 115℃; for 1.33333h;91.5%
In 1-methyl-pyrrolidin-2-one; toluene at 20 - 110℃; for 3.5h; Inert atmosphere;90%
42518-98-9

5-chlorothiophene-2-carbonyl chloride

4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrobromide

366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With sodium carbonate In water; acetone at 10 - 50℃; for 0.5h;95%
With triethylamine In ethyl acetate at 10 - 20℃; for 1h;10 g
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    TIANFUCHEM--366789-02-8-- Rivaroxaban in stock

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    Our company engages in Electronic chemicals such as OLED,Photoresist chemical,Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

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  • Casno:

    366789-02-8

    New production CAS 366789-02-8 with best quality

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    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is (Wen Xi Pharma), including three subs

  •  Zhuozhou Wenxi import and Export Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

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  • Rivaroxaban

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    366789-02-8

    Rivaroxaban

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    Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical i

  •  Wuhan Han Sheng New Material Technology Co.,Ltd

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:17798174412

    Address:Room 401, Floor 4, Building 3-1, Guandong Science and Technology Industrial Park, Jiayuan Road, Guandong Street, Donghu Hi tech Development Zone, Wuhan

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  • Casno:

    366789-02-8

    Rivaroxaban CAS 366789-02-8 Manufacturer of High Quality and Low Price

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    Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

    Hubei Hanways Pharmchem Co.,Limited is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. Now we

  •  HANWAYS CHEMPHARM CO.,LIMITED

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-18502787239(whatsapp)

    Address:18-1-802, Green Garden, Jianghan District, Wuhan 430023, China

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    366789-02-8

    Factory Supply API Powder Rivaroxaban 99% purity Rivaroxaban raw powder with safe delivery

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    We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

    Xi'an faithful BioTech Co., Ltd. is located in the beautiful city of xian. We are mainly engaged in the production of pharmaceutical intermediates, natural active ingredients, nat

  •  Xi'an Faithful Biotech Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-13137770562

    Address:Room 503,Unit 2,Building 3 ,TianLangDaXingJun, Daxing East Road, Lianhu District

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  • Casno:

    366789-02-8

    Rivaroxaban/ LIDE PHARMA- Factory supply / Best price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

    LIDE PHARMACEUTICALS LIMITED is one of the fastest growing pharmaceutical company in China. We have developed strategic partnership with our manufacturing associates having state o

  •  LIDE PHARMACEUTICALS LIMITED

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-25-58409506

    Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.

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  • Rivaroxaban,

  • Casno:

    366789-02-8

    Rivaroxaban,

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    Rivaroxaban Chemical Properties Melting point 228-229°C Boiling point 732.6±60.0 °C(Predicted) density 1.460±0.06 g/cm3(Predicted) storage temp. Inert atmosphere,2-8°C pka 13.36±0.46(Predicted) Safe

    SHANGHAI MINSTAR CHEMICAL CO., LTD. is a leading, experienced, professional supplier of API & intermediates, plant extract, food additive, fine chemicals and industry chemicals, et

  •  Shanghai Minstar Chemical Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:0086-21-18019205509

    Address:BUILDING 8, NO.1098, CHUANSHA ROAD, SHANGHAI, CHINA

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  • Rivaroxaban WITH BEST PRICE

  • Casno:

    366789-02-8

    Rivaroxaban WITH BEST PRICE

    Min.Order: 1 Kilogram

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    Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

    Baoji Guokang Healthchem co.,ltd located in Baoji High-tech Zone,is epitomizing international,cooperative and honest.We are a young company full of action and energy,and our profes

  •  Baoji Guokang Healthchem co.,ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-917-3909592

    Address:China

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  • Rivaroxaban CAS: 366789-02-8

  • Casno:

    366789-02-8

    Rivaroxaban CAS: 366789-02-8

    Min.Order: 1 Gram

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    Rivaroxaban CAS: 366789-02-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

    Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speciali

  •  Qingdao Beluga Import and Export Co., LTD

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+8613854236000

    Address:qingdao

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  • cas 366789-02-8 Rivaroxaban Chinese manufacturer

  • Casno:

    366789-02-8

    cas 366789-02-8 Rivaroxaban Chinese manufacturer

    Min.Order: 1 Kilogram

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    We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful d

    Shanghai Terui OP New Material Technology Co., Ltd. is a company dedicated to the research and development, production and sales of organic compounds, pharmaceutical intermediates

  •  Shanghai Terui OP New Material Technology Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 18126314766

    Address:Room 901, Building 11, Lane 388, Baifu Road, Fengxian District, Shanghai,

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  • Rivaroxaban

  • Casno:

    366789-02-8

    Rivaroxaban

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

    Shandong Hanjiang Chemical Co., Ltd. is located in Zibo City, Shandong Province, China. It is a biotechnology enterprise engaged in the R&D, production and sales of drugs, steroids

  •  Shandong Hanjiang Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86 18369939125

    Address:No.25A Qilu Industrial Park

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  • Rivaroxaban CAS NO.366789-02-8

  • Casno:

    366789-02-8

    Rivaroxaban CAS NO.366789-02-8

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0

    best price,best quality and fast delivery assurance available in sample product and customization with years of export experience along with excellent quality, advanced services and competitive prices the quality of products conform u

    Changchun Artel Import and Export Trade Co., Ltd. is located in Changchun City, Jilin Province. It is a high-tech modern private enterprise specializing in the research, developme

  •  Changchun Artel lmport and Export trade company

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-0431-80543058

    Address:Dianshi Plazza,Chaoyang District

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