Journal of the American Chemical Society p. 95 - 98 (2017)
Update date:2022-08-04
Topics:
Shang, Ming
Wang, Xiaoxu
Koo, Seung Moh
Youn, Jennifer
Chan, Jessica Z.
Yao, Wenzhi
Hastings, Brian T.
Wasa, Masayuki
A method for enantioselective direct α-amination reaction catalyzed by a sterically "frustrated" Lewis acid/Br?nsted base complex is disclosed. Cooperative functioning of the Lewis acid and Br?nsted base components gives rise to in situ enolate generation from monocarbonyl compounds. Subsequent reaction with hydrogen-bond activated dialkyl azodicarboxylates delivers α-aminocarbonyl compounds in high enantiomeric purity.
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Doi:10.1021/ol3020607
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