Enantioselective preparation of asymmetrically protected 2-propanoyl-1,3-propanediol derivatives: Toward the total synthesis of Kazusamycin A

Article abstract of DOI:10.1016/j.tetasy.2004.01.007

The preparation of enantiomerically pure 2-propanoyl-1,3-propanediol derivatives, key intermediates in our studies on total synthesis of the potent antitumor compound Kazusamycin A are described. After various enzymatic protocols for desymmetrization of t