Bulletin of the Chemical Society of Japan p. 2156 - 2161 (1984)
Update date:2022-08-03
Topics:
Ueki
Shinozaki
Synthesis of bis left bracket N,N-diallyl- left bracket D-Ala**2, L-Leu**5 right bracket -enkephalyl right bracket cystine, which is expected to be a selective opioid delta -receptor antagonist, was studied. The mercapto group of cysteine was protected by the dimethylphosphinothioyl(Mpt) group. For the removal of this group without damaging the allyl moiety, new mild removal conditions by use of KF/18-crown-6 in a solvent mixture of acetonitrile-methanol are proposed. Bis left bracket D-Ala**2, L-Leu**5 right bracket -enkephalyl right bracket cystine was also prepared in a similar manner.
View MoreShanghai Sunwise Chemical Co., Ltd
website:http://www.sunwisechem.com
Contact:86-021-33883180
Address:Room 10E, Building G, Westlink Center, No. 2337 Gudai Road, Minhang District, Shanghai, China PC: 201100
Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd
Contact:0086-10-64430626
Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.
Lishui Nanming Chemical Co., Ltd(expird)
Contact:+86-0578-2134101,2697830
Address:No.19 Tongji Road Shuige Industrial zone
Yingkou Sanzheng New Technology Chemical Industry Co., Ltd.
Contact:+86-417-2927806
Address:yingkou
Contact:+86-512-69561895
Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China
Doi:10.1016/j.bmc.2009.07.028
(2009)Doi:10.1246/cl.1978.791
(1978)Doi:10.1021/ja01860a049
(1940)Doi:10.1016/S0022-328X(00)92671-8
(1980)Doi:10.1016/0040-4020(78)80203-8
(1978)Doi:10.1007/BF00962116
(1989)