Bulletin of the Chemical Society of Japan p. 2156 - 2161 (1984)
Update date:2022-08-03
Topics:
Ueki
Shinozaki
Synthesis of bis left bracket N,N-diallyl- left bracket D-Ala**2, L-Leu**5 right bracket -enkephalyl right bracket cystine, which is expected to be a selective opioid delta -receptor antagonist, was studied. The mercapto group of cysteine was protected by the dimethylphosphinothioyl(Mpt) group. For the removal of this group without damaging the allyl moiety, new mild removal conditions by use of KF/18-crown-6 in a solvent mixture of acetonitrile-methanol are proposed. Bis left bracket D-Ala**2, L-Leu**5 right bracket -enkephalyl right bracket cystine was also prepared in a similar manner.
View MoreChina Synchem Technology Co.,Ltd
website:http://www.cnsynchem.com
Contact:+86-0552-4929311
Address:No.217 Daqing Road
Contact:+49-9398-993127
Address:Untertorstr. 27
Jiangsu Kolod Food Ingredients Co.,Ltd
Contact:86-518-85110578
Address:South of Weier Road,Guanyun Development Zone
Zibo Shiji Zhonglian Pharmaceutical Technology Co., Ltd.
Contact:+86-533-3075187
Address:66 Xin'er Road, Linzi District, Zibo City, Shandong, China
Shanghai united Scientific Co.,Ltd.
Contact:+86-21-53535353
Address:28F No.900 huaihai Road Shanghai China
Doi:10.1016/j.bmc.2009.07.028
(2009)Doi:10.1246/cl.1978.791
(1978)Doi:10.1021/ja01860a049
(1940)Doi:10.1016/S0022-328X(00)92671-8
(1980)Doi:10.1016/0040-4020(78)80203-8
(1978)Doi:10.1007/BF00962116
(1989)
