Bulletin of the Chemical Society of Japan p. 2156 - 2161 (1984)
Update date:2022-08-03
Topics:
Ueki
Shinozaki
Synthesis of bis left bracket N,N-diallyl- left bracket D-Ala**2, L-Leu**5 right bracket -enkephalyl right bracket cystine, which is expected to be a selective opioid delta -receptor antagonist, was studied. The mercapto group of cysteine was protected by the dimethylphosphinothioyl(Mpt) group. For the removal of this group without damaging the allyl moiety, new mild removal conditions by use of KF/18-crown-6 in a solvent mixture of acetonitrile-methanol are proposed. Bis left bracket D-Ala**2, L-Leu**5 right bracket -enkephalyl right bracket cystine was also prepared in a similar manner.
View MoreNanjing Fayekong Chemcial Co.,Ltd(expird)
Contact:86-25-58813444
Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
Zhonghao (dalian) Research and Design Institute of Chemical Industry Co., Ltd
Contact:+86 411 84674606
Address:201, Huangpu Road , Shahekou District, Dalian ,116023-China
Taizhou YOJOY Chemical Co., Ltd.
Contact:13857143241
Address:Yangfu Industrial Park, Xianju, Zhejiang, P. R. China
Beijing Stable Chemcial Co.ltd
Contact:86-10-63785052
Address:A1301 Technological Edifice. No.4 FuFeng Road,FengTai District, Beijing. China
Jinan Yijialian Economic and Trade Development Co., Ltd.
Contact:+86 0531-66729596
Address:jinan
Doi:10.1016/j.bmc.2009.07.028
(2009)Doi:10.1246/cl.1978.791
(1978)Doi:10.1021/ja01860a049
(1940)Doi:10.1016/S0022-328X(00)92671-8
(1980)Doi:10.1016/0040-4020(78)80203-8
(1978)Doi:10.1007/BF00962116
(1989)