Bioorganic and Medicinal Chemistry Letters p. 1830 - 1834 (2009)
Update date:2022-09-26
Topics:
Kothandaraman, Shankaran
Donnely, Karla L.
Butora, Gabor
Jiao, Richard
Pasternak, Alexander
Morriello, Gregori J.
Goble, Stephen D.
Zhou, Changyou
Mills, Sander G.
MacCoss, Malcolm
Vicario, Pasquale P.
Ayala, Julia M.
DeMartino, Julie A.
Struthers, Mary
Cascieri, Margaret A.
Yang, Lihu
A series of novel 1-aminocyclopentyl-3-carboxyamides incorporating substituted tetrahydropyran moieties have been synthesized and subsequently evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog 59 was found to posses potent antagonistic activity.
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