S. H. Shelke et al. / Bioorg. Med. Chem. Lett. 22 (2012) 6373–6376
6375
Table 2
References and notes
Antimicrobial antifungal activity of compounds 6a–r
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Compound
MW
MIC
l
g/mL (
lM)
E. coli
S. aureus
C. albicans
A. Niger
ATCC 25922 ATCC 25923 ATCC 10231 ATCC 9029
6a
6b
6c
6d
6e
6f
6g
6h
6i
6j
6k
6l
6m
6n
6o
6p
6q
6r
352.47 25(70.92)
386.92 25(64.61)
404.91 25(61.74)
370.46 12.5(33.74) 25(67.48)
381.49 25(65.53)
365.49 25(60.40)
386.92 12.5(32.30) 12.5(32.30) 50(129.22) 50(129.22)
421.36 12.5(29.66) 25(59.33)
439.35 25(56.90) 25(56.90)
404.91 6.25(15.43) 12.5(30.87) 12.5(30.87) 25(61.74)
416.94 12.5(29.98) 12.5(29.98) 12.5(29.98) 12.5(29.98)
400.94 12.5(31.17) 12.5(31.17) 6.25(15.58) 12.5(31.17)
368.88 25(67.77)
435.39 25(57.42)
453.38 25(55.14)
418.94 25(59.67)
430.97 25(58.00)
414.97 25(60.24)
25(70.92)
50(141.85) 50(141.85)
50(129.23) 50(129.23) 50(129.23)
25(61.74)
50(123.48) 50(123.48)
12.5(33.74) 12.5(33.74)
12.5(32.76) 12.5(32.76)
25(65.53)
50(120.80) 12.5(30.20) 12.5(30.20)
50(118.66) 50(118.66)
50(113.80) 50(113.80)
25(67.77)
12.5(33.88) 12.5(33.88)
11. Karegoudar, P.; Karthikeyan, M. S.; Prasad, D. J.; Mahalinga, M.; Holla, B. S.;
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12.5(28.71) 12.5(28.71) 12.5(28.71)
25(55.14)
25(59.67)
25(58.00)
25(60.24)
1.56(4.70)
—
12.5(27.57) 12.5(27.57)
6.25(14.91) 6.25(14.91)
6.25(14.50) 6.25(14.50)
12.5(30.12) 6.25(15.06)
Ciprofloxacin 331.4 0.78(2.35)
Fluconazole 306.27
—
—
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—
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1.56 (5.09)
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Out of all the compounds 6j, 6k, 6l showed good activities for all
the tested species at MICs 6.25–12.5 g/mL (15.43–33.74 M).
l
l
Compound 6g showed good antibacterial activities against both
species, where as compounds 6d, 6h and 6n showed good antibac-
terial activities against E. coli and S. aureus respectively. It was
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phenyl or 4-chloro benzyl group at 2-position of thiazole ring.
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Acknowledgements
The authors P.C.M. and V.D.B. are thankful University Grants
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