Journal of Organic Chemistry p. 4880 - 4885 (1981)
Update date:2022-08-05
Topics:
Ayral-Kaloustian, Semiramis
Agosta, William C.
Preparation of cis-4-tert-butyl-cis-3-hydroxycyclohexaneacetonitrile (2) and the parent cis-3-hydroxycyclohexaneacetonitrile (1) is described.In intermediates leading to 2 severe crowding at axially substituted C(3) leads to unusual reactions, including rapid intramolecular oxonium ion formation at 0-5 deg C, abnormally easy hydride reduction of a nitrile, and formation of an open-chain hemiacetal that is relatively stable to aqueous acid.
View MoreShenyang Mole pharmaceutical Technology Development Co.,Ltd
Contact:+86-24-31204918/13889278616
Address:No.44, wanliutang road, shenhe District of Shenyang
SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD
Contact:+86-755-82412922
Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District
Contact:+86-310-7092106
Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Contact:(1) 206-3550089
Address:5115 NE 8TH PL, Renton, WA 98059 USA
Contact:+86-15850770348
Address:51 OF XIANGFANGCUN ROAD, Nanjing 210002, China
Doi:10.1021/jm00194a004
(1979)Doi:10.1002/anie.200904745
(2010)Doi:10.1021/jm00195a003
(1979)Doi:10.1021/jm00195a014
(1979)Doi:10.1039/b315817a
(2004)Doi:10.1021/jm0306475
(2004)
