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  • 162881-26-7 Structure
  • Basic information

    1. Product Name: Phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide
    2. Synonyms: BIS(2,4,6-TRIMETHYLBENZOYL)PHENYLPHOSPHINE OXIDE;IRGACURE(R) 819;PHENYLBIS(2,4,6-TRIMETHYLBENZOYL)PHOSPHINE OXIDE;Phosphine oxide, phenylbis(2,4,6-trimethylbenzoyl)-;Phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide ,99%;Photoinitiator XBPO;Photoinitiator 819;Phenylbis(2,4,6-triMethylbenzoyl)phosphine oxide 97%, powder
    3. CAS NO:162881-26-7
    4. Molecular Formula: C26H27O3P
    5. Molecular Weight: 418.46
    6. EINECS: 423-340-5
    7. Product Categories: Miscellaneous;Organic Photoinitiators;Polymerization Initiators
    8. Mol File: 162881-26-7.mol
    9. Article Data: 25
  • Chemical Properties

    1. Melting Point: 131-135 °C(lit.)
    2. Boiling Point: 589.968 °C at 760 mmHg
    3. Flash Point: 310.602 °C
    4. Appearance: /powder
    5. Density: 1.173 g/cm3
    6. Vapor Pressure: 6.78E-14mmHg at 25°C
    7. Refractive Index: 1.588
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: acetone, acetonitrile, toluene, and hexanedioldiacrylate: solubl
    10. Water Solubility: acetone, acetonitrile, toluene, and hexanedioldiacrylate: soluble
    11. CAS DataBase Reference: Phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide(CAS DataBase Reference)
    12. NIST Chemistry Reference: Phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide(162881-26-7)
    13. EPA Substance Registry System: Phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide(162881-26-7)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 43-53
    3. Safety Statements: 22-24-37-61
    4. WGK Germany: -
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 162881-26-7(Hazardous Substances Data)

162881-26-7 Usage

Uses

Different sources of media describe the Uses of 162881-26-7 differently. You can refer to the following data:
1. Phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide is a useful research chemical compound.
2. 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid is a useful building block and has been used in the synthesis of the pesticide Cyclaniliprole.
3. Versatile UV photoinitiator for radical polymerization of unsaturated resins, especially pigmented formulations.

Check Digit Verification of cas no

The CAS Registry Mumber 162881-26-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,8,8 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 162881-26:
(8*1)+(7*6)+(6*2)+(5*8)+(4*8)+(3*1)+(2*2)+(1*6)=147
147 % 10 = 7
So 162881-26-7 is a valid CAS Registry Number.
InChI:InChI=1/C26H27O3P/c1-16-12-18(3)23(19(4)13-16)25(27)30(29,22-10-8-7-9-11-22)26(28)24-20(5)14-17(2)15-21(24)6/h7-15H,1-6H3

162881-26-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide

1.2 Other means of identification

Product number -
Other names Photoinitiator XBPO

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:162881-26-7 SDS

162881-26-7Synthetic route

bis (2,4,6-trimethylbenzoyl) phenylphosphine
620596-61-4

bis (2,4,6-trimethylbenzoyl) phenylphosphine

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
With Nitrogen dioxide In toluene for 1.5h; Inert atmosphere;94.7%
With dihydrogen peroxide at 55℃; for 2h; Temperature; Reagent/catalyst;93.2%
With dihydrogen peroxide at 55℃; for 2h; Temperature;93.9%
Dichlorophenylphosphine
644-97-3

Dichlorophenylphosphine

mesitylene-2-carboxylic acid chloride
938-18-1

mesitylene-2-carboxylic acid chloride

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Stage #1: Dichlorophenylphosphine With sodium amalgam In toluene for 1h; Reflux; Inert atmosphere;
Stage #2: With tert-butyl alcohol In toluene for 1h; Inert atmosphere; Reflux;
Stage #3: mesitylene-2-carboxylic acid chloride In toluene at 40℃; for 1h; Reagent/catalyst; Inert atmosphere;
91%
Stage #1: With sodium In toluene at 20 - 98℃; Heating / reflux;
Stage #2: Dichlorophenylphosphine In toluene for 17h; Heating / reflux;
Stage #3: mesitylene-2-carboxylic acid chloride With peracetic acid; 3-methylpentan-3-ol more than 3 stages;
87%
Stage #1: With sodium In toluene at 20 - 98℃; Heating / reflux;
Stage #2: Dichlorophenylphosphine In toluene for 17h; Heating / reflux;
Stage #3: mesitylene-2-carboxylic acid chloride With peracetic acid; 3-methylpentan-3-ol Product distribution / selectivity; more than 3 stages;
86%
C26H31O3P

C26H31O3P

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
With vanadium(IV) bis(2,4-pentanedionate); dihydrogen peroxide at 20℃; for 16.5h; Reagent/catalyst;89%
With dihydrogen peroxide at 20℃; for 10h; Time;40 g
C26H27Cl4P

C26H27Cl4P

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
With dihydrogen peroxide In toluene78%
mesitylene-2-carboxylic acid chloride
938-18-1

mesitylene-2-carboxylic acid chloride

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Stage #1: With sodium; pentaphenylcyclopentaphosphane In toluene at 20℃; Heating / reflux;
Stage #2: With tert-butyl alcohol In toluene at 98 - 110℃; for 17h; Heating / reflux;
Stage #3: mesitylene-2-carboxylic acid chloride With dihydrogen peroxide more than 3 stages;
P,P-dichlorophenylphosphine oxide
824-72-6

P,P-dichlorophenylphosphine oxide

mesitylene-2-carboxylic acid chloride
938-18-1

mesitylene-2-carboxylic acid chloride

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Stage #1: With N,N,N,N,-tetramethylethylenediamine; sodium In xylene at 105 - 110℃;
Stage #2: P,P-dichlorophenylphosphine oxide In toluene for 23.16h; Heating / reflux;
Stage #3: mesitylene-2-carboxylic acid chloride With dihydrogen peroxide more than 3 stages;
4-isopropylthioxanthone

4-isopropylthioxanthone

2-isopropyl-9H-thioxanthen-9-one
5495-84-1

2-isopropyl-9H-thioxanthen-9-one

A

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

B

2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)-benzyl)-phenyl)-2-methylpropan-1-one
474510-57-1

2-hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)-benzyl)-phenyl)-2-methylpropan-1-one

triphenylphosphine
603-35-0

triphenylphosphine

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium / tert-butyl alcohol; chlorobenzene; toluene / Reflux
1.2: 20 - 100 °C
2.1: tert-butyl alcohol; chlorobenzene; water; toluene / 0.5 h / 80 °C
3.1: dihydrogen peroxide / tert-butyl alcohol; chlorobenzene; water; toluene / 2 h / 40 - 50 °C
View Scheme
Dichlorophenylphosphine
644-97-3

Dichlorophenylphosphine

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium / toluene / 16.5 h / Inert atmosphere; Reflux
1.2: Inert atmosphere; Reflux
2.1: dihydrogen peroxide / methanol; water / 2.5 h / -5 - 20 °C / Inert atmosphere
3.1: dimethyl amine / 1,2-dichloro-ethane / -5 - 60 °C / Inert atmosphere
4.1: dihydrogen peroxide; vanadium(IV) bis(2,4-pentanedionate) / 16.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: trimethylsilan / toluene / 0.75 h / 20 °C / Inert atmosphere
1.2: 3 h / 70 - 80 °C / Inert atmosphere
2.1: toluene / 4.5 h / 50 - 100 °C / Inert atmosphere
3.1: Nitrogen dioxide / toluene / 1.5 h / Inert atmosphere
View Scheme
phenylphosphane
638-21-1

phenylphosphane

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dihydrogen peroxide / methanol; water / 2.5 h / -5 - 20 °C / Inert atmosphere
2: dimethyl amine / 1,2-dichloro-ethane / -5 - 60 °C / Inert atmosphere
3: dihydrogen peroxide; vanadium(IV) bis(2,4-pentanedionate) / 16.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / pentane; hexane / 0.75 h / -30 °C / Inert atmosphere; Cooling with ethanol-dry ice
1.2: Cooling
2.1: triethylamine / toluene / 25 - 28 °C / Inert atmosphere
3.1: diethyl ether; tetrahydrofuran / 20 °C / Inert atmosphere
4.1: dihydrogen peroxide / 40 - 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / pentane; hexane / 0.75 h / -30 °C / Inert atmosphere; Cooling with ethanol-dry ice
1.2: Cooling
2.1: triethylamine / toluene / 25 - 28 °C / Inert atmosphere
3.1: diethyl ether; tert-butyl methyl ether / 20 °C / Inert atmosphere
4.1: dihydrogen peroxide / 40 - 50 °C
View Scheme
(trichloromethyl)mesitylene
707-74-4

(trichloromethyl)mesitylene

Dichlorophenylphosphine
644-97-3

Dichlorophenylphosphine

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Stage #1: (trichloromethyl)mesitylene; Dichlorophenylphosphine With magnesium In tetrahydrofuran Reflux;
Stage #2: With hydrogenchloride; dihydrogen peroxide In water
49 g
1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aluminum (III) chloride; hydrogenchloride / 2 h / 20 °C
2: magnesium / tetrahydrofuran / Reflux
View Scheme
Multi-step reaction with 3 steps
1: aluminum (III) chloride / 3 h / 20 - 45 °C
2: toluene
3: dihydrogen peroxide / toluene
View Scheme
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride / 26 - 30 °C / Inert atmosphere; Large scale
2.1: thionyl chloride / 35 °C / Large scale
3.1: sodium; potassium tert-butylate; L-serin / toluene / 7 h / 90 °C / Inert atmosphere
3.2: 7 h / 88 - 100 °C
4.1: dihydrogen peroxide / water / 6 h / 55 - 65 °C / pH 6 - 8
View Scheme
chlorobenzene
108-90-7

chlorobenzene

mesitylene-2-carboxylic acid chloride
938-18-1

mesitylene-2-carboxylic acid chloride

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: phosphan; pyridine / diethyl ether / 2 h / 95 - 110 °C / Inert atmosphere
1.2: 2 h / 45 - 50 °C
2.1: dihydrogen peroxide / diethyl ether / 2 h / 30 - 45 °C / Inert atmosphere
View Scheme
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / 35 °C / Large scale
2.1: sodium; potassium tert-butylate; L-serin / toluene / 7 h / 90 °C / Inert atmosphere
2.2: 7 h / 88 - 100 °C
3.1: dihydrogen peroxide / water / 6 h / 55 - 65 °C / pH 6 - 8
View Scheme
Phenylphosphin-P.P-bis-kaliumcarboxylat

Phenylphosphin-P.P-bis-kaliumcarboxylat

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 60 °C / Inert atmosphere
2: diethyl ether; tetrahydrofuran / 20 °C / Inert atmosphere
3: dihydrogen peroxide / 40 - 50 °C
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 60 °C / Inert atmosphere
2: diethyl ether; tert-butyl methyl ether / 20 °C / Inert atmosphere
3: dihydrogen peroxide / 40 - 50 °C
View Scheme
C8H5O4P(2-)*2Li(1+)

C8H5O4P(2-)*2Li(1+)

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / toluene / 25 - 28 °C / Inert atmosphere
2: diethyl ether; tetrahydrofuran / 20 °C / Inert atmosphere
3: dihydrogen peroxide / 40 - 50 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / toluene / 25 - 28 °C / Inert atmosphere
2: diethyl ether; tert-butyl methyl ether / 20 °C / Inert atmosphere
3: dihydrogen peroxide / 40 - 50 °C
View Scheme
C12H17N2O4P

C12H17N2O4P

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether; tetrahydrofuran / 20 °C / Inert atmosphere
2: dihydrogen peroxide / 40 - 50 °C
View Scheme
Phenylphosphin-P.P-bis-natriumcarboxylat

Phenylphosphin-P.P-bis-natriumcarboxylat

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; phosphorus trichloride / diethyl ether / 1 h / Inert atmosphere; Reflux
2: diethyl ether; tetrahydrofuran / 20 °C / Inert atmosphere
3: dihydrogen peroxide / 40 - 50 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine; phosphorus trichloride / diethyl ether / 1 h / Inert atmosphere; Reflux
2: diethyl ether; tert-butyl methyl ether / 20 °C / Inert atmosphere
3: dihydrogen peroxide / 40 - 50 °C
View Scheme
phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

2-chloropropionyl chloride
625-36-5

2-chloropropionyl chloride

C29H30ClO4P

C29H30ClO4P

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 10 - 35℃; for 7h;62%
phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

acrylic acid n-butyl ester
141-32-2

acrylic acid n-butyl ester

A

mesytaldehyde
487-68-3

mesytaldehyde

B

C23H27O4P

C23H27O4P

C

4-Oxo-4-<2,4,6-trimethyl-phenyl>-but-2-ensaeure-butylester
30313-12-3

4-Oxo-4-<2,4,6-trimethyl-phenyl>-but-2-ensaeure-butylester

D

(2,4,6-Trimethylbenzoyl) phenyl phosphine oxide

(2,4,6-Trimethylbenzoyl) phenyl phosphine oxide

Conditions
ConditionsYield
In benzene-d6 at 24℃; Irradiation;
phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

methyl 3,3-dimethyl-2-methylenebutanoate
79593-50-3

methyl 3,3-dimethyl-2-methylenebutanoate

A

mesytaldehyde
487-68-3

mesytaldehyde

B

C18H24O3

C18H24O3

C

C24H29O4P

C24H29O4P

D

(2,4,6-Trimethylbenzoyl) phenyl phosphine oxide

(2,4,6-Trimethylbenzoyl) phenyl phosphine oxide

Conditions
ConditionsYield
In benzene-d6 at 24℃; Irradiation;
phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

C26H27O3P(1-)

C26H27O3P(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Reagent/catalyst; Solvent; Electrolysis;
phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

phenyl(2,4,6-trimethylbenzoyl)phosphinic acid

phenyl(2,4,6-trimethylbenzoyl)phosphinic acid

Conditions
ConditionsYield
In acetonitrile at 20℃; Photolysis; Inert atmosphere;
phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

C46H56N2O8P2

C46H56N2O8P2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / chloroform / 0.75 h / 75 °C / Inert atmosphere
1.2: 0.75 h / 75 °C / Inert atmosphere
2.1: dibutyltin(II) dilaurate / toluene / 1 h / 80 °C / Inert atmosphere
View Scheme
phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

formaldehyd
50-00-0

formaldehyd

A

((chloromethyl)(phenyl)phosphoryl)(mesityl)methanone

((chloromethyl)(phenyl)phosphoryl)(mesityl)methanone

B

((hydroxymethyl)(phenyl)phosphoryl) (mesityl)methanone

((hydroxymethyl)(phenyl)phosphoryl) (mesityl)methanone

Conditions
ConditionsYield
With aluminum (III) chloride In chloroform at 75℃; for 0.75h; Inert atmosphere;A 92 mg
B 112 mg
phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide
162881-26-7

phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide

formaldehyd
50-00-0

formaldehyd

A

((3-(hydroxymethyl)-2,4,6-trimethylbenzoyl)(phenyl)phosphoryl) (mesityl)methanone

((3-(hydroxymethyl)-2,4,6-trimethylbenzoyl)(phenyl)phosphoryl) (mesityl)methanone

B

((hydroxymethyl)(phenyl)phosphoryl) (mesityl)methanone

((hydroxymethyl)(phenyl)phosphoryl) (mesityl)methanone

Conditions
ConditionsYield
Stage #1: formaldehyd With aluminum (III) chloride In chloroform at 75℃; for 0.75h; Inert atmosphere;
Stage #2: phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide With aluminum (III) chloride In chloroform at 75℃; for 0.75h; Inert atmosphere;
A 2.9 g
B 1.7 g

162881-26-7Relevant articles and documents

A simple straightforward synthesis of phenylphosphane and the photoinitiator bis(mesitoyl)phenylphosphane oxide (IRGACURE 819)

Gruetzmacher, Hansjoerg,Geier, Jens,Stein, Daniel,Ott, Timo,Schoenberg, Hartmut,Sommerlade, Reinhard H.,Boulmaaz, Souad,Wolf, Jean-Pierre,Murer, Peter,Ulrich, Thomas

, p. 18 - 22 (2008)

A straightforward high-yield synthesis for the photoinitiator bis(2,4,6-trimethylbenzoyl)phenylphosphane oxide (16, IRGACURE 819) involves: i) the reaction of phenyldichlorophosphane, PhPCl2, with sodium to give [Na2(P2Ph2)(tmeda)]6 (5); ii) protonation of 5 with tert-butanol to give 1,2-diphenyldiphosphane, PhHP-PHPh (12); iii) reduction of 12 by sodium to yield [Na(PHPh)x (13); iv) protonation of 13 with tert-butanol to give phenylphosphane PhPH2 (14) in excellent yields; v) reaction of 14 with 2,4,6-trimethylbenzoylchloride (MesCOCI) in presence of the NaOt-Bu formed in steps ii and iv to give bis(2,4,6-trimethylbenzoyl)phenylphosphane 7; vi) oxygenation of 7 with 30% aqueous hydrogen peroxide to give the final product 16. This reaction can be performed in toluene with about 4 vol-% of tmeda as an activator in a one-pot synthesis without changing the solvent. The structures determined by X-ray diffraction of the unique hexameric aggregate 5 and 16 are reported. Schweizerische Chemische Gesellschaft.

Preparation method of photoinitiator

-

Paragraph 0053-0060, (2021/03/24)

The invention provides a preparation method of a photoinitiator phenyl bis(2, 4, 6-trimethylbenzoyl) phosphine oxide, which is characterized by comprising the following steps of (1) reacting water serving as a solvent, phenyl phosphine oxide and 2, 4, 6-trimethylbenzaldehyde serving as raw materials and tert-butyl alcohol salt and pyridinium serving as catalysts to obtain an intermediate compoundshown as a formula I, wherein the equation is as described in the specification, (2) oxidizing the formula I under the action of an oxidizing agent to obtain the target product photoinitiator phenyl bis(2, 4, 6-trimethylbenzoyl) phosphine oxide, wherein the equation is as described in the specification. Tert-butyl alcohol salt and pyridinium are used as catalysts, and the pyridinium has the effectof a phase transfer catalyst, therefore, water can be directly used as a reaction solvent, the use of an organic solvent with toxicity and relatively high price is avoided, and compared with the prior art, the method is more economical and environment-friendly.

Preparation method of bis(2,4,6-trimethylbenzoyl)phenyl phosphine oxide

-

Paragraph 0100-0102; 0107-0109; 0115-0117; 0122-0193, (2021/01/11)

The invention provides a preparation method of bis (2,4,6-trimethylbenzoyl)phenyl phosphine oxide, which comprises the following steps: adding a specific ether compound as a complexing agent in the reaction of sodium sand and phenyl phosphine dichloride, and adding the complexing agent to effectively inhibit the formation of phenyl phosphine sodium polyphosphide and promote the generation of phenyl phosphine sodium; a phenyl phosphine hydrogen process is not needed, so that the process cost is reduced, and the safety of the process is improved; besides, the complexing agent is a polar aproticsolvent, is low in dosage, can reduce the content of organic matters in the wastewater compared with a traditional method adopting a protic solvent as an activating agent or a proton source, has certain environmental benefits and saves the cost.

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