Journal of the American Chemical Society p. 3056 - 3062 (1980)
Update date:2022-07-30
Topics:
Buckley, Thomas F.
Rapoport, Henry
Acylation of alkyl aryl ethers has been observed to be uniquely dependent on the stoichiometry of the Friedel-Crafts catalyst.With 100 molpercent catalyst, acylation proceeds rapidly and in high yield; with large molar excesses of catalyst, the reaction is essentially completely arrested.This inhibition can be reversed by using sterically bulky alkyl groups which effectively prevent complexing between catalyst and aryl ether.Based on these observations, we have developed processes for regioselective intramolecular acylation of either a phenyl or an alkoxylated phenyl ring when both are present.
View MoreHangzhou Haiqiang Chemical Co.,Ltd.
Contact:+86-571-86960370
Address:Add: 5/F, Around Town North Road,No. 10, Hangzhou, Zhejiang,China
Henan PURUI Pharmaceutical Co., Ltd.
website:http://www.puruipharm.com
Contact:17739583555
Address:Yezhuangqiao,Xihua town, Henan province
Contact:13120882795;+86-21-34621078;+86-021-31122318
Address:Suite 2,No.2715 Longwu Road
Xinxiang Junlong Biological Technology Co., Ltd.
website:https://junlongbio.lookchem.com/
Contact:86-13525059581
Address:Xinxiang City, Henan Province
Changzhou Yongxu Chemical Co.,Ltd
Contact:86-0519-85286591
Address:Room 1812,Wanda Plaza B,Xinbei District,Changzhou,Jiangsu,China
Doi:10.1021/om040011r
(2004)Doi:10.1021/ja01855a099
(1941)Doi:10.1021/ja00531a019
(1980)Doi:10.1016/S0008-6215(00)85373-2
(1980)Doi:10.1016/S0008-6215(00)85377-X
(1980)Doi:10.1246/bcsj.81.562
(2008)