12 of 13
AFRADI ET AL.
154.8, 160.5 and 168.8 (11Carom); MS (m/z, %): 302 (M+,
7); Anal. Calcd for C14H12BrN3: C, 55.65; H, 4.00; N,
13.91%. Found: C, 55.89; H, 3.89; N, 14.15%.
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2‐Amino‐5,6‐dimethyl‐4‐propylnicotinonitrile (5 h)
Cream solid; yield 73%, 0.138 g; mp 183–184 °C; IR
(KBr) (νmax, cm−1): 3407, 2961, 2207, 1651, 1540, 1262,
[17] Institute of Medicine (IOM), Dietary Reference Intakes for Thia-
min, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12,
Pantothenic Acid, Biotin, and Choline, National Academy Press,
Washington, DC 1998.
1
994, 502; H NMR (300 MHz, DMSO‐d6): δH 0.84 (t, 3H,
J = 7.0 Hz, CH3), 1.06, 1.16 (2 s, 6H, 2CH3), 3.27–3.34
(m, 2H, CH2), 3.82–3.95 (m, 2H, CH2), 4.83 (s, 2H, NH2);
13C NMR (75 MHz, DMSO‐d6): δC 11.9, 18.2 and 27.8
(3CH3), 54.1 and 55.3 (2CH2), 81.2 (CN), 123.3, 123.5,
130.2, 142.2 and 147.9 (5Carom); MS (m/z, %): 189 (M+,
15); Anal. Calcd for C11H15N3: C, 69.81; H, 7.99; N,
22.20%. Found: C, 70.08; H, 8.23; N, 22.46%.
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ACKNOWLEDGEMENTS
Cintas, Med. Chem. Commun. 2013, 4, 1323.
We gratefully acknowledge financial support from the
Research Council of the University of Science and Arts
of Yazd, Iran.
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