Conformationally defined adrenergic agents. 1. Design and synthesis of novel α2 selective adrenergic agents: Electrostatic repulsion based conformational prototypes

DOI: 10.1021/jm00148a005

Source and publish data:

Journal of Medicinal Chemistry p. 1398 - 1404 (1985)

Update date:2022-08-03

Topics:

Authors:

DeBernardis

Kerkman Kerkman

Winn Winn

Bush Bush

Arendsen

McClellan

Kyncl Kyncl

Basha Basha

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00148a005

A previous report of the adrenergic selectivity of 2- and 6-fluoronorepinephrine prompted us to formulate a hypothesis that accounted for this selectivity on the basis of a conformational preference induced by electrostatic repulsion between the aromatic

Full text of DOI:10.1021/jm00148a005

Products guided by the article

Product name:1-Aminomethyl-5,6-dimethoxy-indan-1-ol

Cas No:749163-83-5

R&D Labs maybe for 749163-83-5

Hangzhou Mole's Science & Technology Co.,Ltd.(expird)

Contact:+86-571-56880228

Address:15F Guodu development Building, NO.182 Zhaohui Road
WD Silicone Co., Ltd

Contact:+86-27-87204219, +86-27-87215023

Address:2402, HuiGu Space-time Building, 8 Forest Road, East Lake Hi-Tech Development Zone
Shenzhen JYMed Technology Co.,Ltd.

website:http://www.jymedtech.com

Contact:+86-755-26612112

Address:1#8,9/F, Biomedicine innovation Industrial Park, No.14, Jinhui Road, Pingshan Sistrict, Shenzhen, China
Cangzhou Senary Chemical Science-tech Co., Ltd

Contact:+86-317-3563899, 3563699

Address:168 Jinde Road, Cangzhou, Hebei, China
Chongqing Werlchem Fine Chemical Co. Ltd

Contact:+86-23-67521957

Address:NO.15,Fortune Road,Yubei District,401121,Chongqing,China

Relevant to this article

Doi:10.1021/ja01505a017
(1960)
Highly Soluble p-Terphenyl and Fluorene Derivatives as Efficient Dopants in Plastic Scintillators for Sensitive Nuclear Material Detection

Doi:10.1002/chem.201700877
(2017)
A D-ribofuranosylenamine as glycosyl acceptor

Doi:10.1016/0008-6215(94)80044-8
(1994)
Conversion between doubly and triply carboxylate bridged Bis(ethylzinc) Complexes and Formation of the (μ-Oxo)tetrazinc Carboxylate [Zn ₄O(Ar^TolCO₂)₆]

Doi:10.1021/om5000503
(2014)
Copper-catalyzed oxyazidation of unactivated alkenes: A facile synthesis of isoxazolines featuring an azido substituent

Doi:10.1021/ol403687k
(2014)
Iridium(iii) complexes adopting 1,2-diphenyl-1H-benzoimidazole ligands for highly efficient organic light-emitting diodes with low efficiency roll-off and non-doped feature

Doi:10.1039/c3tc32092h
(2014)

Article Doi