Conformationally defined adrenergic agents. 1. Design and synthesis of novel α2 selective adrenergic agents: Electrostatic repulsion based conformational prototypes

DOI: 10.1021/jm00148a005

Source and publish data:

Journal of Medicinal Chemistry p. 1398 - 1404 (1985)

Update date:2022-08-03

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Authors:

DeBernardis

Kerkman Kerkman

Winn Winn

Bush Bush

Arendsen

McClellan

Kyncl Kyncl

Basha Basha

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Article abstract of DOI:10.1021/jm00148a005

A previous report of the adrenergic selectivity of 2- and 6-fluoronorepinephrine prompted us to formulate a hypothesis that accounted for this selectivity on the basis of a conformational preference induced by electrostatic repulsion between the aromatic

Full text of DOI:10.1021/jm00148a005

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