Palladium-Catalyzed Synthesis of 2,4-Dienoic Acid Derivatives from Vinylic Halides

Article abstract of DOI:10.1021/jo00319a005

A wide variety of vinylic bromides and iodides have been coupled with acrylic, methacrylic, crotonic, and maleic esters and in some cases with the free acids, nitriles, and amides.In general, good yields of the 2,4-dienoic acid derivatives were obtained.The stereochemistry of the products was determined and the factors influencing the stereoselec-tivity of the reaction were studied.