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Cardiovascular System Cares Natural Puerria Lobata Extract Puerarin 98% Powder
Cas No: 3681-99-0
USD $ 239.0-253.0 / Kilogram 10 Kilogram 100000000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
Puerarin
Cas No: 3681-99-0
USD $ 90.0-98.0 / Kilogram 1 Kilogram 100 Metric Ton/Month Salus Nutra Inc Contact Supplier
Red Kwao Krua Extract
Cas No: 3681-99-0
USD $ 20.0-20.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Greenutra Resource Inc Contact Supplier
Puerarin Manufacturer/High quality/Best price/In stock
Cas No: 3681-99-0
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity Puerarin with high quality cas:3681-99-0
Cas No: 3681-99-0
USD $ 220.0-320.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Puerarin supplier in China
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No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
High quality Puerarin 98% 3681-99-0 with best price
Cas No: 3681-99-0
USD $ 270.0-300.0 / Kilogram 1 Kilogram 5 Metric Ton/Month Kono Chem Co.,Ltd Contact Supplier
Product Pueraria Root,Extract Kudzu Root Extract CAS NO.3681-99-0
Cas No: 3681-99-0
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
High Content Natural Extract Puerarin HACCP manufacturer
Cas No: 3681-99-0
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Supply Puerarin
Cas No: 3681-99-0
No Data 1 1 Ality Chemical Corporation Contact Supplier

3681-99-0 Usage

Chemical Properties

White powder

Uses

beta-adrenergic blocker

Definition

ChEBI: A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.

Uses

Puerarin is a naturally occuring isoflavonoid derived from Chinese medical herb kudzu root and has been used for the treatment of various cardiovascular diseases. Recent sutdies have shown the potenti al of puerarin treatment as a novel approach to lowering the risk of or improving function in ischemia-reperfusion brain injury-related disorders.

Uses

Puerarin is a natural isoflavone isolated from plants of the genus Pueraria used in traditional Chinese herbal medicine. It is biotransformed by intestinal bacteria to give the phytoestrogens daidzein and equol , resulting in antithrombotic, antiallergic, and other salutary effects. When given intraperitoneally, puerarin evokes diverse responses by modulating serotonin receptors. This compound also suppresses lipopolysaccharide-mediated activation of NF-κB in RAW 264.6 macrophages when given at 20-40 μM.
InChI:InChI=1/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21?/m1/s1

3681-99-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (P1886)  Puerarin  >98.0%(HPLC)(T) 3681-99-0 200mg 890.00CNY Detail
TCI America (P1886)  Puerarin  >98.0%(HPLC)(T) 3681-99-0 1g 2,490.00CNY Detail
Sigma-Aldrich (P5555)  Puerarin  analytical standard 3681-99-0 P5555-100MG 787.41CNY Detail
Sigma (82435)  Puerarin  ≥98.0% (HPLC) 3681-99-0 82435-5MG 4,036.50CNY Detail
Sigma-Aldrich (96006)  Puerarin  analytical standard 3681-99-0 96006-10MG 2,337.66CNY Detail

3681-99-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name puerarin

1.2 Other means of identification

Product number -
Other names PUERARIN

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3681-99-0 SDS

3681-99-0Synthetic route

7-hydroxy-4'-methoxy-8-C-(2,3,4,6-tetra-O-benzyl-β-D-glucocopyranosyl)isoflavone

7-hydroxy-4'-methoxy-8-C-(2,3,4,6-tetra-O-benzyl-β-D-glucocopyranosyl)isoflavone

puerarin
3681-99-0

puerarin

Conditions
ConditionsYield
Stage #1: 7-hydroxy-4'-methoxy-8-C-(2,3,4,6-tetra-O-benzyl-β-D-glucocopyranosyl)isoflavone With boron tribromide In dichloromethane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: With methanol In dichloromethane at 0℃; for 0.0833333h; Inert atmosphere;
95%
6-[7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-8-yl]-3,4,5-tris-trimethyl-silanyloxy-tetrahydro-pyran-2-carbaldehyde
1029605-74-0

6-[7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-8-yl]-3,4,5-tris-trimethyl-silanyloxy-tetrahydro-pyran-2-carbaldehyde

puerarin
3681-99-0

puerarin

Conditions
ConditionsYield
Stage #1: 6-[7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-8-yl]-3,4,5-tris-trimethyl-silanyloxy-tetrahydro-pyran-2-carbaldehyde With sodium tetrahydroborate In tetrahydrofuran; ethanol at 0℃; for 0.166667h;
Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol at 0 - 20℃; for 0.25h; Further stages.;
75%
4',7-di-O-benzyldaidzein 8-C-β-D-(2,3,4,6-tetra-O-benzylglucoside)
1242241-66-2

4',7-di-O-benzyldaidzein 8-C-β-D-(2,3,4,6-tetra-O-benzylglucoside)

puerarin
3681-99-0

puerarin

Conditions
ConditionsYield
With boron tribromide In dichloromethane at -78 - 20℃; Inert atmosphere;71%
4',7-di-O-methyl-puerarin
69655-50-1

4',7-di-O-methyl-puerarin

A

puerarin
3681-99-0

puerarin

B

7-O-methylpuerarin

7-O-methylpuerarin

Conditions
ConditionsYield
With trimethylsilyl iodide In acetonitrile for 120h; Heating;A 35%
B 39%
Malonic acid mono-{(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-[7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-8-yl]-tetrahydro-pyran-2-ylmethyl} ester
147899-32-9

Malonic acid mono-{(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-[7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-8-yl]-tetrahydro-pyran-2-ylmethyl} ester

puerarin
3681-99-0

puerarin

Conditions
ConditionsYield
With sodium hydroxide; water Ambient temperature;
Acetic acid (2S,3S,4R,5R,6R)-4,5-diacetoxy-2-{2-acetoxy-6-methoxy-3-[(E)-3-(4-methoxy-phenyl)-acryloyl]-phenyl}-6-acetoxymethyl-tetrahydro-pyran-3-yl ester
69667-95-4

Acetic acid (2S,3S,4R,5R,6R)-4,5-diacetoxy-2-{2-acetoxy-6-methoxy-3-[(E)-3-(4-methoxy-phenyl)-acryloyl]-phenyl}-6-acetoxymethyl-tetrahydro-pyran-3-yl ester

puerarin
3681-99-0

puerarin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Tl(NO3)3; trimethyl orthoformate / methanol
1.2: 84 percent / aq. HCl / methanol / Heating
2.1: 35 percent / Me3SiI / acetonitrile / 120 h / Heating
View Scheme
8-C-β-glucofuranosyl-7,4'-dihydroxyisoflavone

8-C-β-glucofuranosyl-7,4'-dihydroxyisoflavone

A

8-C-α-glucofuranosyl-7,4'-dihydroxyisoflavone

8-C-α-glucofuranosyl-7,4'-dihydroxyisoflavone

B

puerarin
3681-99-0

puerarin

Conditions
ConditionsYield
With hydrogenchloride; water In methanol for 1h; Reflux;
4-(4-methoxyphenethyl)-6-tert-butyl-2-C-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-1,3-dihydroxybenzene

4-(4-methoxyphenethyl)-6-tert-butyl-2-C-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-1,3-dihydroxybenzene

puerarin
3681-99-0

puerarin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium dithionite; trifluoroacetic acid / 11 h / 20 °C
2.1: acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone / water / 14 h / 20 °C
3.1: trichlorophosphate / 0.25 h / 10 °C
3.2: 6 h / 70 °C
4.1: boron tribromide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
4.2: 0.08 h / 0 °C / Inert atmosphere
View Scheme
4-(4-methoxyphenethyl)-6-tert-butylbenzene-1,3-diol

4-(4-methoxyphenethyl)-6-tert-butylbenzene-1,3-diol

puerarin
3681-99-0

puerarin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Molecular sieve
2.1: sodium dithionite; trifluoroacetic acid / 11 h / 20 °C
3.1: acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone / water / 14 h / 20 °C
4.1: trichlorophosphate / 0.25 h / 10 °C
4.2: 6 h / 70 °C
5.1: boron tribromide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
5.2: 0.08 h / 0 °C / Inert atmosphere
View Scheme
2,3,4,6-tetra-O-benzyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
339276-14-1

2,3,4,6-tetra-O-benzyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate

puerarin
3681-99-0

puerarin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Molecular sieve
2.1: sodium dithionite; trifluoroacetic acid / 11 h / 20 °C
3.1: acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone / water / 14 h / 20 °C
4.1: trichlorophosphate / 0.25 h / 10 °C
4.2: 6 h / 70 °C
5.1: boron tribromide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
5.2: 0.08 h / 0 °C / Inert atmosphere
View Scheme
4-(4-methoxyphenethyl)-2-C-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-1,3-dihydroxybenzene

4-(4-methoxyphenethyl)-2-C-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-1,3-dihydroxybenzene

puerarin
3681-99-0

puerarin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone / water / 14 h / 20 °C
2.1: trichlorophosphate / 0.25 h / 10 °C
2.2: 6 h / 70 °C
3.1: boron tribromide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
3.2: 0.08 h / 0 °C / Inert atmosphere
View Scheme
puerarin
3681-99-0

puerarin

C21H24O8

C21H24O8

Conditions
ConditionsYield
With hydrogen; palladium(II) hydroxide In methanol at 20℃; for 4h;95%
6-bromo-hexanoic acid ethyl ester
25542-62-5

6-bromo-hexanoic acid ethyl ester

puerarin
3681-99-0

puerarin

7-O-[5-(ethoxycarbonyl)pentyl]puerarin

7-O-[5-(ethoxycarbonyl)pentyl]puerarin

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 6h; Williamson synthesis;91.14%
diethyl sulfate
64-67-5

diethyl sulfate

puerarin
3681-99-0

puerarin

4',7-diethylpuerarin

4',7-diethylpuerarin

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 4h;91%
puerarin
3681-99-0

puerarin

N-Trimethylsilylacetamide
13435-12-6

N-Trimethylsilylacetamide

7-hydroxy-3-(4-trimethylsilanyloxy-phenyl)-8-(3,4,5-tris-trimethylsilanyloxy-6-trimethylsilanyloxy-methyl-tetrahydro-pyran-2-yl)-chromen-4-one
1029605-66-0

7-hydroxy-3-(4-trimethylsilanyloxy-phenyl)-8-(3,4,5-tris-trimethylsilanyloxy-6-trimethylsilanyloxy-methyl-tetrahydro-pyran-2-yl)-chromen-4-one

Conditions
ConditionsYield
at 175℃; for 0.25h;86%
1-iodo-1-propyne
624-66-8

1-iodo-1-propyne

puerarin
3681-99-0

puerarin

methyl iodide
74-88-4

methyl iodide

4'-n-propyl-7-methylpuerarin

4'-n-propyl-7-methylpuerarin

Conditions
ConditionsYield
Stage #1: 1-iodo-1-propyne; puerarin With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 4h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 12h;
85%
puerarin
3681-99-0

puerarin

3-(2,4-dihydroxy-3-C-β-D-glucosylphenyl)-4-(4-dihydroxyphenyl)-1H-pyrazole

3-(2,4-dihydroxy-3-C-β-D-glucosylphenyl)-4-(4-dihydroxyphenyl)-1H-pyrazole

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 90℃;82%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

puerarin
3681-99-0

puerarin

C25H29O12P

C25H29O12P

Conditions
ConditionsYield
With triethylamine In methanol; tetrachloromethane at 20℃; Atherton-Todd reaction;75%
chloroacetyl chloride
79-04-9

chloroacetyl chloride

puerarin
3681-99-0

puerarin

C23H21ClO10

C23H21ClO10

Conditions
ConditionsYield
With pyridine In chloroform at 0 - 28℃; for 22h; Temperature;72.4%
benzaldehyde
100-52-7

benzaldehyde

puerarin
3681-99-0

puerarin

4'',6''-O-benzylidenepuerarin
934696-18-1

4'',6''-O-benzylidenepuerarin

Conditions
ConditionsYield
With zinc(II) chloride at 20℃; for 3h;70%
With toluene-4-sulfonic acid In acetone at 0 - 20℃;48%
bis(N-pyrrolidinyl)methane
7309-47-9

bis(N-pyrrolidinyl)methane

puerarin
3681-99-0

puerarin

C26H29NO9

C26H29NO9

Conditions
ConditionsYield
With pyridine; hydrogenchloride In methanol; water at 120℃; for 5h; Reagent/catalyst;70%
2-(4-bromobutyl)isoindoline-1,3-dione
5394-18-3

2-(4-bromobutyl)isoindoline-1,3-dione

puerarin
3681-99-0

puerarin

2-{4-[3-(4-Hydroxy-phenyl)-4-oxo-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-4H-chromen-7-yloxy]-butyl}-isoindole-1,3-dione

2-{4-[3-(4-Hydroxy-phenyl)-4-oxo-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-4H-chromen-7-yloxy]-butyl}-isoindole-1,3-dione

Conditions
ConditionsYield
With potassium hydroxide In acetone for 72h; Williamson synthesis; Heating;69%
pivaloyl chloride
3282-30-2

pivaloyl chloride

puerarin
3681-99-0

puerarin

7-O-pivalyl puerarin
934696-09-0

7-O-pivalyl puerarin

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;69%
bis-(diethylamino)methane
102-53-4

bis-(diethylamino)methane

puerarin
3681-99-0

puerarin

3',5'-methylene-diethylamine-puerarin

3',5'-methylene-diethylamine-puerarin

Conditions
ConditionsYield
With pyridine; hydrogenchloride In methanol; water at 80℃; for 6h; Reagent/catalyst;67%
diisopropyl hydrogenphosphonate
1809-20-7

diisopropyl hydrogenphosphonate

puerarin
3681-99-0

puerarin

C27H33O12P

C27H33O12P

Conditions
ConditionsYield
With triethylamine In methanol; tetrachloromethane at 20℃; Atherton-Todd reaction;66.7%
bis(N-pyrrolidinyl)methane
7309-47-9

bis(N-pyrrolidinyl)methane

puerarin
3681-99-0

puerarin

3'-methylene-morpholine-puerarin

3'-methylene-morpholine-puerarin

Conditions
ConditionsYield
With pyridine; hydrogenchloride In methanol; water at 100℃; for 8h; Reagent/catalyst;65%
bis-(dimethylamino)methane
51-80-9

bis-(dimethylamino)methane

puerarin
3681-99-0

puerarin

3'-methylene-dimethylamine-puerarin

3'-methylene-dimethylamine-puerarin

Conditions
ConditionsYield
With pyridine; hydrogenchloride In methanol; water at 60℃; for 4h; Reagent/catalyst;65%
puerarin
3681-99-0

puerarin

C21H17(2)H3O9

C21H17(2)H3O9

Conditions
ConditionsYield
Stage #1: puerarin With [D]-sodium hydroxide; platinum on activated charcoal; water-d2 at 130℃; for 8h; Inert atmosphere;
Stage #2: With formic acid at 130℃; for 1h; Inert atmosphere;
65%
succinic acid anhydride
108-30-5

succinic acid anhydride

puerarin
3681-99-0

puerarin

C25H23O12(1-)*Na(1+)

C25H23O12(1-)*Na(1+)

Conditions
ConditionsYield
With dmap In dichloromethane for 24h; Reflux;63.3%
acetyl chloride
75-36-5

acetyl chloride

puerarin
3681-99-0

puerarin

7-O-acetyl puerarin
934696-10-3

7-O-acetyl puerarin

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;63%
C6H13ClN2O

C6H13ClN2O

puerarin
3681-99-0

puerarin

C27H32N2O10

C27H32N2O10

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane at 10℃; for 24h;62%
diisobutyl phosphite
1189-24-8

diisobutyl phosphite

puerarin
3681-99-0

puerarin

C29H37O12P

C29H37O12P

Conditions
ConditionsYield
With triethylamine In methanol; tetrachloromethane at 20℃; Atherton-Todd reaction;61.7%
O-[(α-D-mannopyranosyl)-(1->6)-(α-D-mannopyranosyl)-(1->3)-β-D-mannopyranosyl]-(1->4)-(1,2-dideoxy-α-D-glucopyrano)-[2,1-d]-2-methyloxazoline
861695-58-1

O-[(α-D-mannopyranosyl)-(1->6)-(α-D-mannopyranosyl)-(1->3)-β-D-mannopyranosyl]-(1->4)-(1,2-dideoxy-α-D-glucopyrano)-[2,1-d]-2-methyloxazoline

puerarin
3681-99-0

puerarin

C47H63NO29
1093135-90-0

C47H63NO29

Conditions
ConditionsYield
With endo-β-N-acetylglucosaminidase from Arthrobactor protophormiae In dimethyl sulfoxide at 23℃; for 2h; pH=7.0; aq. phosphate buffer; Enzymatic reaction;60%
2-Methoxypropene
116-11-0

2-Methoxypropene

puerarin
3681-99-0

puerarin

C24H24O9
934696-19-2

C24H24O9

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetone at 0 - 20℃;59%
di-n-propyl phosphonate
1809-21-8

di-n-propyl phosphonate

puerarin
3681-99-0

puerarin

C27H33O12P

C27H33O12P

Conditions
ConditionsYield
With triethylamine In methanol; tetrachloromethane at 20℃; Atherton-Todd reaction;58.3%
di(N-piperidinyl)methane
880-09-1

di(N-piperidinyl)methane

puerarin
3681-99-0

puerarin

3'-methylene-hexahydropyridine-puerarin

3'-methylene-hexahydropyridine-puerarin

Conditions
ConditionsYield
With pyridine; hydrogenchloride In methanol; water at 80℃; for 8h; Reagent/catalyst;56%
dibutyl hydrogen phosphite
1809-19-4

dibutyl hydrogen phosphite

puerarin
3681-99-0

puerarin

C29H37O12P

C29H37O12P

Conditions
ConditionsYield
With triethylamine In methanol; tetrachloromethane at 20℃; Atherton-Todd reaction;53.3%
methyl chloroformate
79-22-1

methyl chloroformate

puerarin
3681-99-0

puerarin

10-O-methoxyformyl puerarin
934696-16-9

10-O-methoxyformyl puerarin

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;53%

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