Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents

DOI: 10.1016/S0968-0896(99)00169-8

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1907 - 1911 (1999)

Update date:2022-08-03

Topics:

Authors:

Xia, Peng

Yang, Zheng-Yu

Xia, Yi Xia, Yi

Zheng, Yun-Qing

Cosentino, L.Mark

Lee, Kuo-Hsiung

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0968-0896(99)00169-8

In our search for novel anti-HIV agents, seven 17-carboxylated steroid derivatives were synthesized and evaluated as potential anti-HIV agents. Compound 13 exhibited potent anti-HIV activity in acutely infected H9 lymphocytes with EC₅₀ and therapeutic index values of 0.8 μM and 300, respectively.

Full text of DOI:10.1016/S0968-0896(99)00169-8

Products guided by the article

Product name:(3S,3aS,5aS,6R,9aS,9bS)-6-(2-carboxyethyl)-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalene-3-carboxylic acid

Cas No:76763-14-9

R&D Labs maybe for 76763-14-9

hangzhou feixia327

Contact:--

Address:80G, No.1 Building, Guodu Development Mansion, No. 182 Zhaohui Road, Hangzhou City, Zhejiang Province,China.
Hunan Zhongqi Pharmaceutical Co., Ltd

website:http://www.hnzqzy.com

Contact:0730-8722288 13807308622

Address:Wanjiafan Road ,Yueyang Economic And Technological Development Zone ,Hunan,PRC
Shanghai Haoyuan Chemexpress Co., Ltd.

website:https://www.chemexpress.com/

Contact:86-21-58950125

Address:No.3 Building, No.1999, Zhangheng Road, ZhangjiangHighTech Park, Shanghai, P.R.China,201203
LIAOYANG WANRONG CHEMICALS COMPANY LIMITED

Contact:86-419-2390789

Address:XINLI VILLAGE , DONG NINGWEI COUNTY,TAIZIHE DISTRICT, LIAOYANG , LIAONING
Shenzhen JYMed Technology Co.,Ltd.

website:http://www.jymedtech.com

Contact:+86-755-26612112

Address:1#8,9/F, Biomedicine innovation Industrial Park, No.14, Jinhui Road, Pingshan Sistrict, Shenzhen, China

Relevant to this article

Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group

Doi:10.1039/b200155a
(2002)
WCl(η²-C₂Ph₂)(η⁶- C₆Ph₆H): A compound containing a metallacycloheptatriene unitfrom trimerization of diphenylacetylene with W(NMe₃)(η²-C₂Ph₂)₃

Doi:10.1021/om0201009
(2002)
Asymmetric total synthesis of 11-deoxytetrodotoxin,a naturally occurring congener

Doi:10.1021/ja0265153
(2002)
Novel synthesis of L-ribose from D-mannono-1,4-lactone.

Doi:10.1021/ol026141i
(2002)
Novel access to cyclohexane-1,4-diones and 1,4-hydroquinones via radical 1,2-acyl rearrangement on 2-(halomethyl)cyclopentane-1,3-diones using cobaloxime-mediated electroreduction or tributyltin hydride

Doi:10.1016/S0040-4039(02)00163-6
(2002)
Synthesis of new chiral imidazolidine disulfides derived from L-cystine and their application in the enantioselective addition of diethylzinc to aldehydes

Doi:10.1016/S0040-4039(02)00300-3
(2002)

Article Doi