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68497-62-1

Basic Information
CAS No.: 68497-62-1
Name: Pramiracetam
Article Data: 7
Molecular Structure:
Molecular Structure of 68497-62-1 (Pramiracetam)
Formula: C14H27N3O2
Molecular Weight: 269.387
Synonyms: Amacetam;Vinpotropil;
EINECS: 806-175-7
Density: 1.036 g/cm3
Melting Point: 47-48°
Boiling Point: 461 °C at 760 mmHg
Flash Point: 232.6 °C
Appearance: white crystalline powder
Hazard Symbols: Xn
Risk Codes: 22
PSA: 52.65000
LogP: 1.17260
Synthetic route
616-45-5

2-pyrrolidinon

N-[2-(di(isopropyl)amino)ethyl]-2-chloroacetamide

68497-62-1

pramiracetam

Conditions
ConditionsYield
Stage #1: 2-pyrrolidinon With sodium methylate In toluene at 105 - 108℃; for 3h;
Stage #2: N-[2-(di(isopropyl)amino)ethyl]-2-chloroacetamide In toluene at 60 - 70℃;
89.49%
61516-73-2

2-(oxo-pyrrolidin-1-yl)-acetic acid ethyl ester

121-05-1

N',N'-diisopropyl-ethane-1,2-diamine

68497-62-1

pramiracetam

Conditions
ConditionsYield
at 100℃; for 16h;69%
121-05-1

N',N'-diisopropyl-ethane-1,2-diamine

N-(6-bromopyridin-2-yl)-2-(2-oxopyrrolidin-1-yl)acetamide

68497-62-1

pramiracetam

Conditions
ConditionsYield
at 110℃; for 11h; Inert atmosphere;
121-05-1

N',N'-diisopropyl-ethane-1,2-diamine

68497-62-1

pramiracetam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 1.67 h / 0 - 15 °C
2.1: sodium methylate / toluene / 3 h / 105 - 108 °C
2.2: 60 - 70 °C
View Scheme
68497-62-1

pramiracetam

pramiracetam monohydrate

Conditions
ConditionsYield
With water In cyclohexane at 20 - 50℃; for 1.5h; Solvent;90.92%
68497-62-1

pramiracetam

Pramiracetam sulfate

Conditions
ConditionsYield
With sulfuric acid In acetonitrile at 0 - 5℃;84.83%
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Chemistry

IUPAC Name: N-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide
Synonyms of 1-Pyrrolidineacetamide,N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo- (CAS NO.68497-62-1): Pramiracetam [INN] ;  Pramiracetam ; Pramiracetamum ; Pramiracetamum [INN-Latin] ; UNII-4449F8I3LE
CAS NO: 68497-62-1
Molecular Formula of 1-Pyrrolidineacetamide,N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo- (CAS NO.68497-62-1): C14H27N3O2
Molecular Weight: 269.3831
Molecular Structure:

H bond acceptors: 5
H bond donors: 1
Freely Rotating Bonds: 7
Polar Surface Area: 43.86 Å2
Index of Refraction: 1.495
Molar Refractivity: 75.79 cm3
Molar Volume: 259.8 cm3
Surface Tension: 38.7 dyne/cm
Density of 1-Pyrrolidineacetamide,N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo- (CAS NO.68497-62-1): 1.036 g/cm3
Flash Point: 232.6 °C
Enthalpy of Vaporization: 72.18 kJ/mol
Boiling Point: 461 °C at 760 mmHg
Vapour Pressure: 1.11E-08 mmHg at 25°C

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