4,5,8,9-Tetrahydro-8-methyl-9-oxothieno[3',2':5,6]cyclohepta[1,2-b]- pyrrole-7-acetic acid (1). A new anti-inflammatory/analgesic agent

Article abstract of DOI:10.1002/jhet.5570200437

The synthesis of the thienocyclohepta[1,2-b]pyrrole acid 1 from the morpholide 3 is reported. This novel morpholide was prepared by regiospecific alkylation of the dianion of 4-(1,3-dioxobutyl)morpholine with 3-bromomethylthiophene. Subsequent Knorr pyrro