SYNTHETIC STUDIES ON BICYCLOMYCIN I SYNTHESIS OF 1-ALLYL AND BENZOYL-8,10-DIMETHYL-6-METHOXY-5-METHYLENE-8,10-DIAZA-2-OXABICYCLODECANE-7,9-DIONE, WHICH HAVE THE BICYCLO RING SYSTEM FOUND IN ANTIBIOTIC BICYCLOMYCIN

Article abstract of DOI:10.1016/S0040-4039(01)92891-6

Regiospecific cyclization of the alcohol 8 into the bicyclo<4.2.2> compound 12 was achieved via selective activation of the secondary methoxy group and subsequent acid treatment.A side-chain was introduced at the bridge-head position, thus making up the b