Monatshefte fur Chemie p. 1155 - 1164 (1981)
Update date:2022-08-02
Topics:
Martin, Robert
Acylation of 4-methoxy phenol according to Friedel and Crafts, as well as the rearrangement of its esters according to Fries lead always to 2-acyl-4-methoxy phenols or to their demethylated compounds.The unknown 3-acyl-4-methoxyphenols were prepared in two steps: First, the ester is acylated with the corresponding acyl chloride and SnCl4 in nitromethane.In the second step the resulting ketoesters are hydrolysed.This is a general method.The yields of meta-acylphenols are between 40 and 90percent.The isomeric 2-acyl-4-methoxyphenols which were partly unknown or accessible only in low yields have also been prepared for comparative spectral studies (UV, IR, NMR, MS) of ortho- and meta-acylphenols. - Keywords: Friedel-Crafts acylation; Fries rearrangement; Ketoesters; Spectral data
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Doi:10.1021/jm049631k
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(1981)Doi:10.1246/bcsj.54.3466
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(1982)Doi:10.1021/ol0481131
(2004)Doi:10.1023/B:RUBI.0000030129.13466.18
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