ENE REACTION OF THE ACTIVE C=N AND C=O GROUP WITH KETONES. A NOVEL SYNTHESIS OF γ-OXO-α-AMINO- AND γ-OXO-α-HYDROXY-ACIDS.

Article abstract of DOI:10.1016/S0040-4039(01)82946-4

Thermal reaction of butyl N-(p-toluenesulphonyl)iminoacetate and diethyl mesoxalate with ketones leads to the derivatives of γ-oxo-α-amino-acids and γ-oxo-α-hydroxy-acids, respectively.