Journal of Medicinal Chemistry p. 2513 - 2521 (1990)
Update date:2022-08-03
Topics: IC50 Substrate Specificity Structure-Activity Relationship Kinetic Analysis Enzyme assay Inhibition Human leukocyte elastase C-7-substituted cephalosporin Tert-butyl esters
Doherty
Ashe
Barker
Blacklock
Butcher
Chandler
Dahlgren
Davies
Dorn Jr.
Finke
Firestone
Hagmann
Halgren
Knight
Maycock
Navia
O'Grady
Pisano
Shah
et al.
Time-dependent inhibitors of the enzyme human leukocyte elastase have been developed based on the cephem nucleus. A series of cephalosporin tert-butyl esters has been examined, and the activity of these compounds has been found to be very sensitive to C-7
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