Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters

DOI: 10.1021/jm00171a028

Source and publish data:

Journal of Medicinal Chemistry p. 2513 - 2521 (1990)

Update date:2022-08-03

Topics: IC50 Substrate Specificity Structure-Activity Relationship Kinetic Analysis Enzyme assay Inhibition Human leukocyte elastase

Authors:

Doherty Doherty

Ashe Ashe

Barker Barker

Blacklock

Butcher Butcher

Chandler

Dahlgren

Davies Davies

Dorn Jr.

Finke Finke

Firestone

Hagmann Hagmann

Halgren Halgren

Knight Knight

Maycock Maycock

Navia Navia

O'Grady O'Grady

Pisano Pisano

Shah Shah

et al. et al.

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Article abstract of DOI:10.1021/jm00171a028

Time-dependent inhibitors of the enzyme human leukocyte elastase have been developed based on the cephem nucleus. A series of cephalosporin tert-butyl esters has been examined, and the activity of these compounds has been found to be very sensitive to C-7

Full text of DOI:10.1021/jm00171a028

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