Synthesis and structure-activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents

DOI: 10.1016/j.bmc.2004.12.031

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1531 - 1536 (2005)

Update date:2022-08-03

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Authors:

Albrecht, Uwe

Lalk, Michael

Langer, Peter

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Article abstract of DOI:10.1016/j.bmc.2004.12.031

A series of novel 2-vinylchroman-4-ones, analogues of the natural products Aposphaerin A and B, were identified as potent antibiotics. Derivatives exhibit a significant activity against multiresistant strains of S. aureus, such as MRSA (methicillin resist

Full text of DOI:10.1016/j.bmc.2004.12.031

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