Synthesis of 3-keto-4-diazo-5-α-dihydrosteroids as potential irreversible inhibitors of steroid 5-α-reductase

DOI: 10.1016/S0040-4039(00)93612-8

Source and publish data:

Tetrahedron Letters p. 15 - 18 (1980)

Update date:2022-08-05

Topics:

Authors:

Metcalf, Brian W.

Jund, Karin

Burkhart, Joseph P.

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Article abstract of DOI:10.1016/S0040-4039(00)93612-8

3-Keto-4-diazo-5-α-dihydrosteroids are prepared using the Hendrickson diazo transfer reaction on the corresponding β-diketones, which are available from 3-ketoΔ-4-steroids via Li/NH₃ reduction and acylation of the kinetic enolate.

Full text of DOI:10.1016/S0040-4039(00)93612-8

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